High rates of pregnancy after long-term down-regulation of women with severe endometriosis

Marcus SF, Samuel F. Marcus, S F Marcus, Edwards RG, R. G. EDWARDS
American journal of obstetrics and gynecology · 1994 · vol. 171(3) , pp. 812–817 · doi:10.1016/0002-9378(94)90103-1 · PMID:8092234 · W1964986953
Non-randomised trial OA: closed CC0 ⤵ 56 in-corpus citations
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This study investigated the pregnancy rates in women with severe endometriosis who underwent long-term down-regulation treatment.

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Abstract

OBJECTIVE: The purpose of this study was to determine the effects of pituitary down-regulation for several months on the outcome of in vitro fertilization treatment in women with severe endometriosis. STUDY DESIGN: A total of 84 patients with severe endometriosis (grades III and IV) were recruited in a semirandomized prospective study; 69 of these were controls who were given a short protocol with gonadotropin-releasing hormone agonist followed by human menopausal gonadotropin and human chorionic gonadotropin to induce follicular growth. Fifteen treated patients underwent down-regulation for 2 to 7 months and then human menopausal gonadotropin and human chorionic gonadotropin to induce follicular growth. Twenty nonpregnant controls after in vitro fertilization were treated in a similar manner. RESULTS: The pregnancy rates were much high per embryo transfer, 18 of 42 (42.8%), especially in patients in whom in vitro fertilization was carried out during the fourth month of down-regulation. Pregnancy rates in the control group were 17 of 134 (12.7%) (p < 0.001). CONCLUSION: Higher rates of pregnancy are achieved after in vitro fertilization that follows long-term down-regulation in women with extensive endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropin-Releasing Hormone Pituitary Gland Pregnancy Adult Adult Analysis of Variance Analysis of Variance Chorionic Gonadotropin Chorionic Gonadotropin Chorionic Gonadotropin Down-Regulation Down-Regulation Endometriosis Endometriosis Female Female Fertilization in Vitro Fertilization in Vitro Gonadotropin-Releasing Hormone

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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