Relationship between Toll-like receptor-4 and mPGES-1 gene expression in local lesions of endometriosis patients

Hayashi C, Chuyu Hayashi, Fumihisa Chishima, Masahiko Sugitani, Sugitani M, Ichikawa G, Go Ichikawa, Teine Nakazawa‐Watanabe, Teine Nakazawa-Watanabe, Nakazawa-Watanabe T, Sugita K, Kenji Sugita, Manami Suzuki, Suzuki M, Nemoto N, Norimichi Nemoto, Tatsuo Yamamoto, Yamamoto T
American journal of reproductive immunology (New York, N.Y. : 1989) · 2012 · vol. 69(3) , pp. 231–239 · doi:10.1111/aji.12056 · PMID:23252918 · W1985671381
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This study found that TLR4 protein and mPGES-1 mRNA expression were significantly higher in endometriosis lesions compared to eutopic endometrium, with TLR4 mRNA correlating with mPGES-1 mRNA but not COX-2.

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Abstract

PROBLEM: Toll-like receptors (TLRs) are innate immune receptors that mediate the pattern recognition of, and response toward, pathogens and host-derived danger signals. We reported that cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase (mPGES) mRNA were expressed in cases of endometriosis. The relationship between COX-2, mPGES-1, and TLR4 in endometriotic lesions has yet to be determined. METHOD OF STUDY: Endometriosis samples were obtained from 37 patients with endometrial cysts. Endometrial tissues were obtained from patients undergoing surgical procedures for benign gynecological conditions. COX-2, mPGES-1, and TLR4 mRNA expressions were examined by real-time quantitative reverse transcription PCR (qRT-PCR) and mPGES-1, and TLR4 protein localization was examined by immunohistochemistry. RESULTS: TLR4 proteins were mostly located to the glandular epithelium. The immunoreactivities of TLR4 and mPGES-1 from endometriosis lesions were significantly higher than those in eutopic endometrium in the proliferative phase. The expression levels of mPGES-1 mRNA in peritoneal endometriosis were higher than those in eutopic endometrium in the proliferative phase. The expression of TLR4 mRNA correlates with that of mPGES-1 mRNA and not with that of COX-2 in endometriotic lesions. CONCLUSION: Relationship between TLR4 and mPGES-1 mRNA in endometriotic lesions indicate that innate immunity may play an important role in the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Intramolecular Oxidoreductases Ovary Toll-Like Receptor 4 Adult Adult Cyclooxygenase 2 Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Female Female Gene Expression Regulation Gene Expression Regulation Humans Humans Immunity, Innate Immunity, Innate

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (39)

Cited by (15)

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