Dienogest improves human leucocyte antigen-DR underexpression and reduces tumour necrosis factor-α production in peritoneal fluid cells from women with endometriosis

Nobuo Maeda, N. Maeda, Maeda N, Chiaki Izumiya, C Izumiya, Izumiya C, K Taniguchi, Kohei Taniguchi, Taniguchi K, S Matsushima, Matsushima S, Sachio Matsushima, Shizuka Mita, Mita S, S Mita, Yutaka Shimizu, Y Shimizu, Shimizu Y, Fukaya T, T. Fukaya, Tomohiro Fukaya
European journal of obstetrics, gynecology, and reproductive biology · 2014 · vol. 177 , pp. 48–51 · doi:10.1016/j.ejogrb.2014.03.019 · PMID:24793935 · W2137897711
Other OA: closed CC0 ⤵ 32 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Dienogest treatment of peritoneal fluid cells from women with endometriosis reduced tumor necrosis factor-alpha production and improved human leukocyte antigen-DR underexpression.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To determine the immunological effect of dienogest (DNG), an oral anti-endometriosis drug, on peritoneal fluid (PF) macrophages collected from women with endometriosis. Although it has been suggested that DNG has direct effects on endometriotic cells, including decreased cell proliferation and decreased anti-inflammatory cytokine production, the effects of DNG on PF cells are unclear. STUDY DESIGN: The effects of DNG on PF cells from 34 women with endometriosis and 22 women without endometriosis (controls) were investigated. Expression of human leucocyte antigen (HLA)-DR in PF macrophages, obtained from the peritoneal cavity during laparoscopic surgery, was determined by flow cytometry. HLA-DR expression was measured again after PF cells had been cultured for 72 h in a humidified atmosphere at 37 °C in 5% CO₂-95% air with or without DNG. After 72 h of incubation, the concentration of pro-inflammatory tumour necrosis factor (TNF)-α in the media was measured by enzyme-linked immunosorbent assay. RESULTS: HLA-DR expression was lower in PF macrophages from women with endometriosis compared with controls. However, after DNG treatment, HLA-DR expression in PF macrophages from women with endometriosis was increased to the same level as in controls. The TNF-α concentration in the media was decreased by DNG. CONCLUSIONS: DNG can restore the antigen-presenting ability of PF macrophages by increased HLA-DR expression, and may have an anti-inflammatory effect on PF macrophages in women with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis HLA-DR Antigens Hormone Antagonists Macrophages Nandrolone Peritoneal Diseases Tumor Necrosis Factor-alpha Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Cells, Cultured Cells, Cultured Endometriosis Endometriosis Female Female HLA-DR Antigens HLA-DR Antigens

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

Cited by (33)

Source provenance

europepmc
last seen: 2026-10-13T06:10:10.580696+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:13:34.636433+00:00
unpaywall
last seen: 2026-10-13T06:25:51.201866+00:00
License: CC0 · commercial use OK