Expression and possible role of interleukin-10 receptors in patients with adenomyosis

Xiaoyan Qin, Qin X, Hualing Zhang, Zhang H, Fei Wang, Wang F, Xue J, Jing Xue, Wen Z, Zeqing Wen
European journal of obstetrics, gynecology, and reproductive biology · 2012 · vol. 161(2) , pp. 194–198 · doi:10.1016/j.ejogrb.2011.12.011 · PMID:22226539 · W2029767872
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This study investigated the expression of interleukin-10 receptors in patients with adenomyosis to understand their potential role in the condition.

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Abstract

OBJECTIVE: To investigate the expression and potential roles of interleukin-10 receptor 1 (IL-10R1) and interleukin-10 receptor 2 (IL-10R2) in adenomyosis. STUDY DESIGN: This prospective study examined 33 women with histologically proven adenomyosis and 21 women without adenomyosis who had undergone hysterectomy for non-endometrial pathology. Comparative immunohistochemistry was used to evaluate the expression and localization of IL-10R1 and IL-10R2. Tissue sections were immunostained with goat anti-human interleukin-10 receptor alpha and rabbit anti-human interleukin-10 receptor beta antibodies. The presence and localization of IL-10R1 and IL-10R2 were evaluated microscopically throughout the menstrual cycle in eutopic and ectopic endometrial tissues of women with adenomyosis, and the results were compared with those for normal endometrium. RESULTS: IL-10R1 and IL-10R2 were mainly expressed by epithelial cells in both women with adenomyosis and controls. Epithelial expression of IL-10R1 and IL-10R2 was higher in adenomyotic samples than in eutopic endometrium of women with adenomyosis or normal endometrium. Moreover, epithelial expression of IL-10R1 was higher in eutopic endometrium of women with adenomyosis than in normal endometrium. Epithelial expression of IL-10R1 showed cyclic variation in eutopic endometrium of women with adenomyosis and normal endometrium, with elevated expression in secretory-phase tissues compared with proliferative-phase tissues. CONCLUSIONS: Intrinsic abnormalities concerning IL-10 and IL-10 receptors may be present in eutopic and ectopic endometria of women with adenomyosis. These findings suggest that IL-10 receptors may be involved in the immunotolerant and/or anti-inflammatory process of adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Endometrium Interleukin-10 Receptor alpha Subunit Interleukin-10 Receptor beta Subunit Uterine Diseases Adult Adult Analysis of Variance Analysis of Variance Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Interleukin-10 Receptor alpha Subunit Interleukin-10 Receptor alpha Subunit Interleukin-10 Receptor beta Subunit

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (16)

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