Mifepristone Inhibited the Expression of B7-H2, B7-H3, B7-H4 and PD-L2 in Adenomyosis

Xiaoyan Qin, Wenjing Sun, Chong Wang, Mingjiang Li, Xingbo Ζhao, Changzhong Li, Hui Zhang
In: Research Square · 2021 · doi:10.21203/rs.3.rs-196690/v1 · W4249203662
preprint OA: green CC0 ⤵ 1 in-corpus citation
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This study found increased expression of B7-H2, B7-H3, B7-H4, and PD-L2 in adenomyosis, which was subsequently decreased by mifepristone treatment.

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Abstract

Abstract BackgroundThe immune mechanism was shown to be involved in the development of adenomyosis. The current study aims to evaluate the expression of immune checkpoint B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis and to explore the effect of mifepristone on the expression of these immune checkpoints. MethodsThe expression of B7-H2, B7-H3, B7-H4 and PD-L2 in normal endometria and adenomyosis treated with or without mifepristone was determined by immunohistochemistry analysis.ResultsIn adenomyosis, the expression of B7-H2, B7-H3 and B7-H4 was increased in the eutopic and ectopic endometria compared with normal endometria, both in the proliferative and secretory phase. Moreover, the expression of B7-H2 and B7-H3 was higher in adenomyotic lesions than in the corresponding eutopic endometria, both in the proliferative and secretory phase. The expression of PD-L2 was higher in adenomyotic lesions than in normal endometria, both in the proliferative and secretory phase. In secretory phase but not the proliferative phase, the expression of B7-H4 and PD-L2 in adenomyotic lesion showed a significantly higher level than that in the corresponding eutopic endometria. In normal endometria and eutopic endometria, the expression of B7-H4 showed elevated expression in proliferative phase compared with that in the secretory phase, while this change altered in ectopic endometria with decreased B7-H4 expression in proliferative phase than the secretory phase. In addition, the expression of B7-H2, B7-H3, B7-H4 and PD-L2 was significantly decreased in adenomyosis after treated with mifepristone.ConclusionsExpression of immune checkpoint proteins B7-H2, B7-H3, B7-H4 and PD-L2 is up-regulated in adenomyosis and down-regulated with mifepristone treatment. The data suggests that the B7 immunomodulatory molecules are involved in the pathophysiology of adenomyosis.

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adenomyosis

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