Research Progress in Drug Treatment of Adenomyosis

Zhenyue Qin, Zhiyong Dong, Junling Liu, Shoufeng Zhang, Huihui Wang, Mingyue Bao, Weiwei Wei, Ruxia Shi, Jiming Chen, Bairong Xia
In: Journal of Gynecology and Obstetrics · 2022 · vol. 10(2) , pp. 139 · doi:10.11648/j.jgo.20221002.22 · W4290718188
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This review summarizes drugs for adenomyosis treatment, finding they relieve symptoms and inhibit lesions but lack specificity and may recur after withdrawal, necessitating personalized treatment plans.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This paper is a literature-based review that summarizes drug treatments for adenomyosis, retrieving studies from MEDLINE, Embase, Cochrane Library, CENTRAL, and ClinicalTrials.gov (2000 to March 2022) using search terms for adenomyosis and related terms. It reports that drug therapy can relieve symptoms, inhibit lesion proliferation, and may be used alongside surgical treatment, but that efficacy and adverse reactions are linked to duration of use, there is no specific single drug for adenomyosis, and symptoms/lesions can recur after discontinuation. The authors note that some studies using combination regimens have achieved certain results. This paper is centrally about adenomyosis — it reviews the research progress in drug treatment approaches for adenomyosis.

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Abstract

Background: Adenomyosis is caused by endometrial glands and stroma invading the myometrium. It is more common in parturients after the age of 30. At present, there are many drugs for the treatment of adenomyosis, and drug treatment is also one of the important treatments for adenomyosis. Objective: To summarize the drugs that can be used for the treatment of adenomyosis, hoping to be helpful to the clinical treatment. Method: Relevant studies were retrieved from the MEDLINE, Embase, Cochrane Library, CENTRAL and ClinicalTrials.gov. The retrieval time range was from January 2000 to March 2022. English search terms included "(treatment)","(adenomyosis) OR (endometrioma) OR (adenomyoma)". Result: Drug therapy can relieve the clinical symptoms of patients, inhibit the proliferation of lesions, and cooperate with surgical treatment to improve the curative effect. The efficacy and adverse reactions of the drug are closely related to the duration of use. At present, there is no specific drug for the treatment of adenomyosis, and there is a certain degree of recurrence after drug withdrawal. Some clinical scholars have adopted a combination regimen for the treatment of adenomyosis and achieved certain results. Conclusion: About the drug treatment of adenomyosis, it is necessary to personalize the treatment plan by combining the severity of the patients' clinical symptoms, age, fertility needs, patients' economic conditions, whether they can regulate the use of drugs, and the adverse reactions after the use of drugs.

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Condition tags

adenomyosisendometrioma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

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last seen: 2026-06-10T17:14:06.276822+00:00
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