Morphologic characteristics of endometriosis in the mouse model: application to toxicology

Foster WG, Warren G. Foster, W G Foster, Myra Ruka, Ruka MP, M P Ruka, Paula J. Gareau, Gareau P, P Gareau, Foster RA, RA Foster, R A Foster, Edward G. Janzen, E G Janzen, Janzen EG, J Z Yang, Jack Yang, Yang JZ
Canadian journal of physiology and pharmacology · 1997 · vol. 75(10-11) , pp. 1188–1196 · doi:10.1139/cjpp-75-10-11-1188 · PMID:9431442 · W2061797778
Lab / animal OA: closed CC0 ⤵ 11 in-corpus citations
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This study developed a mouse model of surgically induced endometriosis to show that estrogen and a potential environmental contaminant (4-CDE) promote implant growth, while TCDD inhibits it in the presence of estrogen.

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Abstract

Surgically induced endometriosis in the mouse has been described as a model to investigate the effect of environmental pollutants on the growth of endometriotic implants. The objectives of this study were to evaluate a modified surgical procedure to induce endometriosis and validate the model by comparing the effects of estrogen, 4-chlorodiphenyl ether (4-CDE) as a possible estrogenic contaminant, and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a contaminant with predominantly anti-estrogenic activities, on the growth of endometrial implants. Uterine strips (1.0 x 4.0 mm2) were autotransplanted to multiple sites in the abdomen of sexually mature female B6C3F1 mice (n = 33), which were randomly assigned to the following groups: intact control (n = 4); ovariectomized (OVX, n = 9); OVX and treated with 4-CDE (n = 6); OVX and treated with 17 beta-estradiol (E2, n = 9); and OVX and treated with E2 plus TCDD (n = 5). Endometrial implants survived warm ischemia regardless of implant site and appeared as small clear spherical or ovoid fluid-filled cysts. The diameter of the endometrial cysts in the OVX animals was significantly (p < 0.0001) smaller compared with the intact animals and OVX animals replaced with E2 or 4-CDE. In contrast, TCDD treatment inhibited the growth of endometrial cysts in the presence of estrogen. We conclude that autotransplantation of uterine slices to multiple abdominal sites results in formation of endometriotic cysts that are responsive to estrogen, and that environmental contaminants possess the potential to affect the survival and growth of endometrial cysts. Therefore, we concluded that the mouse endometriosis model described in this paper has applications to investigate the possible role of environmental pollutants in the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Animals Animals Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Estradiol Estradiol Estradiol Female Female Halogenated Diphenyl Ethers Halogenated Diphenyl Ethers Mice Mice Mice, Inbred Strains Mice, Inbred Strains Organ Size

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

Cited by (11)

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