Endometriosis

David L. Olive
In: Current Opinion in Obstetrics and Gynecology · 1992 · vol. 4(3) , pp. 380–387 · doi:10.1097/00001703-199206000-00007 · W2058092968
article OA: closed CC0 ⤵ 10 in-corpus citations
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Recent advances clarify the transplantation hypothesis for endometriosis pathogenesis and the link between implants and pelvic pain, while the relationship with infertility is less clear and new treatment modalities are being developed.

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This review examines recent advances in the understanding and management of endometriosis, noting that while pathogenesis remains controversial, the transplantation hypothesis is the most widely accepted theory for generating ectopic endometrium. The authors highlight emerging evidence regarding factors critical to implant growth and maintenance, alongside a clarified cause-effect relationship between the disease and pelvic pain, whereas its link to infertility appears less definitive. Treatment trials have helped clarify the roles of specific interventions and new modalities developed based on novel pathophysiologic mechanisms. This paper is centrally about endometriosis, serving as a broad overview of its current pathogenic theories, clinical relationships with pain and infertility, and evolving treatment strategies.

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Abstract

Endometriosis is a commonly encountered disease, yet most aspects of its pathogenesis, pathophysiology, and treatment remain controversial. Recent advances, however, have increased our understanding of this enigmatic disorder. While many theories persist regarding the pathogenesis of endometriosis, the transplantation hypothesis is by far the most widely accepted. Evidence continues to accumulate in support of this theory as the primary mode of generating ectopic endometrium. In addition, recent work has begun to uncover factors critical to the growth and maintenance of such implants. Advances in pathophysiology have strongly suggested a cause-effect relationship between endometriosis and pelvic pain; conversely, such a relationship between implants and infertility is becoming more tenuous. Treatment trials, in both animals and humans, have begun to clarify the role of specific interventions in combating endometriosis. In addition, as new pathophysiologic mechanisms have been proposed, an intriguing array of new modalities have been developed as treatment options.
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Endometriosis advances in understanding and management - David L. Olive Endometriosis is a commonly encountered disease, yet most aspects of its pathogenesis, pathophysiology, and treatment remain controversial. Recent advances, however, have increased our understanding of this enigmatic disorder. While many theories persist regarding the pathogenesis of endometriosis, the transplantation hypothesis is by far the most widely accepted. Evidence continues to accumulate in support of this theory as the primary mode of generating ectopic endometrium. In addition, recent work has begun to uncover factors critical to the growth and maintenance of such implants. Advances in pathophysiology have strongly suggested a cause-effect relationship between endometriosis and pelvic pain; conversely, such a relationship between implants and infertility is becoming more tenuous. Treatment trials, in both animals and humans, have begun to clarify the role of specific interventions in combating endometriosis. In addition, as new pathophysiologic mechanisms have been proposed, an intriguing array of new modalities have been developed as treatment options.

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Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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