Inflammatory reaction in endometriotic tissue: an immunohistochemical study

U. Cirkel, Cirkel U, Ochs H, H. Ochs, Mues B, B Mues, Zwadlo G, G. Zwadlo, Sorg C, C Sorg, Clemens Sorg, H P Schneider, H. P. G. Schneider, Schneider HP
European journal of obstetrics, gynecology, and reproductive biology · 1993 · vol. 48(1) , pp. 43–50 · doi:10.1016/0028-2243(93)90052-e · PMID:8449261 · W2030207298
Other OA: closed CC0 ⤵ 16 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-16 ⓘ

This immunohistochemical study investigated the presence and characteristics of inflammatory cells within endometriotic tissue.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

A panel of monoclonal antibodies specific for macrophage subtypes appearing in early (27E10), down-regulatory (RM3/1) and late (25F9) stages of inflammation had been applied to 20 endometriotic implants of 14 women. Of those patients 9 were in the follicular phase of the cycle, two on danazol, one on LHRH-analogue (buserelin) and another two on oral contraceptives. Beside the macrophage subsets, antibodies against T4, T8 lymphocytes as well as proliferating cells (EN7/44 and Ki67) were examined. In all specimens immunologically competent cells could be detected to a varying degree and within the same implant different stages of inflammation were discernible. Endometriosis presented with signs of early inflammation indicated by 27E10+ macrophages and CD4+ lymphocytes (15 specimens) and with down-regulatory, late inflammatory reactions as shown by RM3/1+, 25F9+ macrophages and CD8+ lymphocytes (19 biopsies). Additionally, in 14 specimens cells of the EN7/44+ and Ki67+ type was detected. These preliminary results showed no significant correlation to either extension of endometriotic implants or adhesions or concomitant therapy and clearly indicate, that there is an immunological dynamic process within the lesion itself in addition to that one of the peritoneal fluid.

My notes (saved in your browser only)

Condition tags

mesh:D004716endometriosis

MeSH descriptors

Endometriosis Endometritis Adult Adult Antibodies, Monoclonal Antibodies, Monoclonal Biopsy Biopsy Buserelin Buserelin Buserelin Contraceptives, Oral, Hormonal Contraceptives, Oral, Hormonal Contraceptives, Oral, Hormonal Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (36)

Cited by (16)

Source provenance

europepmc
last seen: 2026-10-15T06:08:49.021275+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:59:37.277143+00:00
unpaywall
last seen: 2026-10-15T06:24:24.424788+00:00
License: CC0 · commercial use OK