One‐year follow‐up of ovarian reserve by three methods in women after laparoscopic cystectomy for endometrioma and benign ovarian cysts

Marta Kostrzewa, Jacek R Wilczyński, Ewa Głowacka, Monika Żyła, Krzysztof Szyłło, Grzegorz Stachowiak
International Journal of Gynecology & Obstetrics · 2019 · vol. 146(3) , pp. 350–356 · doi:10.1002/ijgo.12884 · PMID:31197834 · W2949630087
article OA: closed CC0 ⤵ 28 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Laparoscopic cystectomy for endometriomas significantly decreased anti-Müllerian hormone levels by 3 months, with no further decline at 12 months, while antral follicle count and ovarian volume remained stable.

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Abstract

OBJECTIVE: To determine the long-term impact of laparoscopic cystectomy for endometriomas and benign cysts on ovarian reserve and selection of the most effective method of assessment. METHODS: The present study was carried out between November 2013 and December 2016. Participants were assigned to laparoscopic cystectomy for diagnosed unilateral benign ovarian cysts and divided into groups: the endometrioma group (EG) (n=35) and the other benign ovarian tumor group (OG) (n=35). Before and at 3 and 12 months after the procedure, transvaginal ultrasonography was performed to assess antral follicle count (AFC) and ovarian volume (OvVol); laboratory tests were ordered for anti-Műllerian hormone (AMH) serum concentration assays. Pregnancy rates were counted in a 12-month follow-up. Statistica12 software was used for analysis. RESULTS: The present study included 70 women aged 18-40 years. AMH serum concentration decreased significantly 3 months after laparoscopic cystectomy (4.89 ± 3.66 ng/mL to 3.45 ± 3.37 ng/mL; P<0.001). A greater decrease of AMH concentrations was observed in the EG (45.39% vs 14.87%; P=0.021). Twelve months of observation revealed a suppression in the drop of the AMH concentration, while AFC and OvVol remained unaffected. The likelihood of spontaneous pregnancy was three times higher in the OG (hazard ratio [HR] 3.57, 95% confidence interval [CI] 1.08-12.5). CONCLUSION: There was a significant decline in AMH levels in the EG 3 months after cystectomy. No further fall in AMH concentration was observed in the 12-month follow-up. The serum AMH concentration could be considered a valuable marker for ovarian reserve assessment after laparoscopic cystectomy.

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Condition tags

mesh:D004715endometrioma

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Laparoscopy Ovarian Cysts Ovarian Reserve Adolescent Adult Anti-Mullerian Hormone Biomarkers Biomarkers Endometriosis Female Follow-Up Studies Humans Laparoscopy Ovarian Cysts Ovarian Follicle Ovarian Follicle Pregnancy Pregnancy Rate

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (28)

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