Anti-Mullerian Hormone Changes Following Laparoscopic Ovarian Cystectomy: A Prospective Comparative Study

Hye Yon Cho, Sung-taek Park, Sung‐Ho Park, Min Sun Kyung
In: International Journal of Women's Health · 2021 · vol. Volume 13 , pp. 691–698 · doi:10.2147/ijwh.s320264 · PMID:34285593 · PMC8285238 · W3180051525
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Abstract

PURPOSE: To investigate whether laparoscopic ovarian cystectomy (LOC) affects ovarian reserve. PATIENTS AND METHODS: In 46 premenopausal women, who underwent either LOC (study group, n=26) or laparoscopic myomectomy (LM) (control group, n=20), serum anti-Mullerian hormone (AMH) levels were measured pre-operatively (AMH0), and postoperatively at 7 days (AMH1), 2 months (AMH2), and 6 months (AMH3). Changes in AMH from baseline level (AMH0) in each group were compared. RESULTS: =0.001). CONCLUSION: Compared to LM, serum AMH level showed a minimal decrease after 1 week following LOC, which did not revert to normal over 6 months of follow-up. In addition, a significant decline of ovarian reserve at postoperative 6 months was significantly more frequent in the LOC group, suggesting that LOC may have more adverse effects on ovarian reserve compared to the LM (control) group. Thus, care is required during the LOC procedure, specifically in women with bilateral tumors.

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