Short-Term Impact of Laparoscopic Cystectomy on Ovarian Reserve Tests in Bilateral and Unilateral Endometriotic and Nonendometriotic Cysts

Kerime Nazlı Salihoglu, Salihoğlu KN, Kerime N Salihoğlu, Berna Dilbaz, Derya Akdağ Cırık, Cırık DA, Ozelci R, Runa Ozelci, Runa Özelçi, Enis Özkaya, Ozkaya E, Enis Ozkaya, Leyla Mollamahmutoğlu, Mollamahmutoğlu L
Journal of Minimally Invasive Gynecology · 2016 · vol. 23(5) , pp. 719–725 · doi:10.1016/j.jmig.2016.02.018 · PMID:26940401 · W2290722004
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Laparoscopic cystectomy decreased AMH levels in both endometriotic and nonendometriotic cysts, with similar short-term changes in ovarian reserve markers regardless of cyst type.

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Abstract

Study objectiveTo evaluate the short-term changes in ovarian reserve markers after laparoscopic cystectomy performed for endometriotic and nonendometriotic cysts.DesignProspective case-control study (Canadian Task Force classification II-2).SettingThe Reproductive Endocrinology Clinic of a training and research hospital.PatientsThirty-four women with endometrioma ≥ 4 mm (group 1) and 33 women with nonendometriotic cysts of matched size (group 2) who underwent surgery during the same period.InterventionsThe follicular phase follicle-stimulating hormone (FSH), estradiol (E2), and antimüllerian hormone (AMH) levels and the antral follicle count (AFC) of both groups were analyzed preoperatively and 2 months after laparoscopic cystectomy. The pre- and postoperative values were compared within the same group and between the 2 groups.Measurement and main resultsPreoperative FSH and E2 levels were similar in both groups. However, preoperative AMH levels and AFC were significantly lower in group 1 (endometrioma) compared with group 2 (nonendometrioma; p = .004 and p = .025, respectively). In both groups there was a significant decrease in the AMH levels after surgery (3.1 ± 1.9 ng/mL to 2.5 ± 1.6 ng/mL, p < .001, and 5.7 ± 3.7 ng/mL to 4.8 ± 3.3 ng/mL, p = .04). AMH levels exhibited a significant decrease in the unilateral and bilateral endometrioma groups after cystectomy (p < .001 and p = .025, respectively). However, preoperative and postoperative changes in AMH and AFC were similar in groups 1 and 2 for both unilateral and bilateral cysts (p = .586 and p = .267).ConclusionPreoperative AMH and AFC levels are lower in both unilateral and bilateral endometriomas compared with nonendometriotic cysts. The AMH levels decreased after cystectomy in both endometriotic and nonendometriotic cysts. However, in the short-term period the amount of change in ovarian reserve tests in both unilateral and bilateral cysts was similar for both endometrioma and nonendometriotic cysts.

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Condition tags

endometriosis

MeSH descriptors

Anti-Mullerian Hormone Cystadenoma, Mucinous Endometriosis Estradiol Follicle Stimulating Hormone Ovarian Cysts Ovarian Neoplasms Ovarian Reserve Teratoma Adult Anti-Mullerian Hormone Biomarkers Case-Control Studies Cystadenoma, Mucinous Endometriosis Estradiol Female Follicle Stimulating Hormone Humans Laparoscopy

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