Long-Term Follow-Up Of Anti-Mullerian Hormone Levels After Laparoscopic Endometrioma Cystectomy

Anh Duy Nguyen, Nguyen Duy Anh, Nguyen Thi Thu Ha, Nguyen Manh Tri, Do Khac Huynh, Đỗ Tuấn Đạt, Do Tuan Dat, Phan Thi Huyen Thuong, Toan Khac Nguyen, Nguyen Khac Toan, Anh Đức Trần, Tran Anh Duc, Nguyen Duc Hinh, Nguyễn Đức Hinh, Hoang Văn Tong, Hoang Van Tong
International journal of medical sciences · 2022 · vol. 19(4) , pp. 651–658 · doi:10.7150/ijms.69830 · PMID:35582413 · PMC9108410 · W4225772873
article OA: gold CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Serum AMH levels significantly declined one year after laparoscopic endometrioma cystectomy, with bilateral endometriomas, cyst size, and preoperative AMH levels influencing the outcome.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This prospective longitudinal study evaluated 104 reproductive-age women with unilateral or bilateral endometriomas undergoing laparoscopic endometrioma cystectomy by measuring serum anti-Mullerian hormone (AMH) preoperatively and at 1, 3, 6, and 12 months postoperatively, and used multivariate linear regression to identify factors associated with AMH level changes. Median AMH declined significantly from 3.77 ng/mL preoperatively to 1.60, 1.66, 1.67, and 1.72 ng/mL at 1, 3, 6, and 12 months, with the decrease being less pronounced at 12 months than during the first 6 months, and AMH at 12 months higher than at 3 and 6 months. The rate of AMH decrease differed by laterality, with bilateral endometriomas showing consistently larger declines and unilateral cases showing a smaller decline by 12 months. The paper does not provide a major stated limitation in the provided text, but it reports that some participants received GnRHa or COCs for varying durations and that AMH was not measured in those who conceived between 6 and 12 months, which could affect follow-up consistency. This paper is centrally about endometriosis — it assesses long-term AMH (ovarian reserve) changes after laparoscopic endometrioma cystectomy.

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Abstract

The study aims to evaluate long-term ovarian reserve change by serum anti-Mullerian hormone (AMH) level and determine the factors that affect the changes after laparoscopic endometrioma cystectomy. Methods: In a prospective longitudinal study, 104 patients with unilateral (n=77) and bilateral (n=27) endometrioma underwent laparoscopic endometrioma cystectomy. AMH levels were measured preoperatively and at 1, 3, 6, and 12 months postoperatively. Multivariate linear regression analysis was performed to determine factors related to AMH level changes. Results: Median preoperative AMH levels significantly declined from 3.77 ng/mL to 1.60 ng/mL (P<0.001), 1.66 ng/mL (P<0.001), 1.67 ng/mL (P<0.001), and 1.72 ng/mL (P<0.001) at 1, 3, 6, and 12 months postoperatively, respectively. The rate of decrease in AMH was unchanged six months after surgery, 52.2%, 53.7%, 54.8% at 1, 3, 6 months, respectively, and declined to 43.2% at 12 months. Although most factors were associated with AMH level changes in monovariant linear regression, multivariant linear regression analysis showed only three factors that reached the statistical significance, including bilateral endometriomas, mean size of the endometrioma, and preoperative AMH levels. Conclusions: Serum AMH levels decline significantly after laparoscopic cystectomy of endometriomas but recovered at 12 months compared with the first 6 months with unilateral endometrioma. Bilateral endometriomas, size of the cyst, and preoperative AMH levels might independently affect AMH levels at 12 months after surgery.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Laparoscopy Laparoscopy Laparoscopy Laparoscopy Laparoscopy Laparoscopy Laparoscopy Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone

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