Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas

Kitajima M, Michio Kitajima, Dolmans MM, Marie-Madeleine Dolmans, Marie‐Madeleine Dolmans, Olivier Donnez, Donnez O, Masuzaki H, Hideaki Masuzaki, Michelle Soares, Jacques Donnez, Donnez J
Fertility and sterility · 2014 · vol. 101(4) , pp. 1031–1037 · doi:10.1016/j.fertnstert.2013.12.049 · PMID:24502890 · W1997742717
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This study investigated ovarian cortex from ovaries with endometriomas, observing enhanced follicular recruitment and atresia in the affected cortex.

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Abstract

OBJECTIVE: To evaluate the effects of endometriomas on the regulation of early follicular development. DESIGN: Histologic analysis of prospectively collected biopsy samples. SETTING: Research unit in a university hospital. PATIENT(S): Women <40 years of age who have ovarian endometriomas. INTERVENTION(S): Biopsy of healthy cortex from ovaries affected by endometriomas (≤ 4 cm) and contralateral ovaries without cysts. MAIN OUTCOME MEASURE(S): Histomorphological staging of early follicles, measurement of follicle, oocyte, and oocyte nucleus diameters, immunohistochemistry of proliferating cell nuclear antigen, and caspase-3. RESULT(S): Thirteen cortical samples from ovaries with endometriomas and 13 samples from contralateral ovaries without endometriomas were evaluated. Cortex from ovaries with endometriomas contained significantly more morphologically atretic early follicles than cortex from contralateral ovaries without cysts. These follicles showed cleaved caspase-3 immunostaining. Diameters of primordial follicles and oocytes were decreased in cortex from ovaries with endometriomas, whereas early follicles with proliferating cell nuclear antigen-positive granulosa cells (GCs) were significantly increased in number. CONCLUSION(S): Ovaries with endometriomas, which may be more prone to local pelvic inflammation, showed activated follicular recruitment and atresia of early follicles. The potential contribution of inflammation to follicle "burnout" in case of endometriomas is discussed.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Follicular Atresia Follicular Atresia Ovarian Follicle Adult Adult Endometriosis Endometriosis Female Female Humans Humans Ovarian Follicle Ovarian Follicle Young Adult Young Adult

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (50)

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