Metabolomic biomarkers of endometriosis: A systematic review

L.V. Adamyan, L.G. Pivazyan, Evdokiya Zarova, J.S. Avetisyan, Anastasia Laevskaya, Antonina Sarkisova, A.A. Stepanian
In: Journal of Endometriosis and Uterine Disorders · 2024 · vol. 7 , pp. 100077 · doi:10.1016/j.jeud.2024.100077 · W4394566421
Systematic review / meta-analysis OA: diamond CC0 ⤵ 14 in-corpus citations
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This systematic review identified amino acids, succinate, citrate, lactate, acetone, 3-hydroxybutyrate, acylcarnitines, and sphingomyelins as potential metabolomic biomarkers for endometriosis.

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Abstract

The purpose of this systematic review was to identify potential metabolomic biomarkers of endometriosis in plasma, serum, peritoneal fluid, follicular fluid, urine, endometrial tissue samples of patients with endometriosis. Search was conducted in electronic databases including PubMed, The Cochrane Library, ClinicalTrials.gov, Embase, MEDLINE, Web of Science. Randomized controlled trials, observational, cohort and case control studies, comparing metabolomic profiles in women with laparoscopically confirmed endometriosis and women with laparoscopically confirmed absence of endometriosis were included. 17 studies were included in the qualitative synthesis. According to the results of our study, potential metabolomic biomarkers for the diagnosis of endometriosis were shown to be amino acids, including threonic acid and 3-hydroxybutyric acid, succinate, citrate, lactate, acetone, 3-hydroxybutyrate, acylcarnitines and sphingomyelins. Perturbations in metabolites levels reflect disruption of metabolic pathways in the presence of the disease. Due to the controversy of published data, further research and highlights are needed for the determination of specific metabolites.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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