Identification of anti-α-enolase autoantibody as a novel serum marker for endometriosis

Nabeta M, Motowo Nabeta, Yasuhito Abe, Abe Y, Lisa Kagawa, Kagawa L, Ryuma Haraguchi, Haraguchi R, Kito K, Katsumi Kito, Ueda N, Norifumi Ueda, Atsuro Sugita, Sugita A, Yokoyama M, Motofumi Yokoyama, Kusanagi Y, Yasuki Kusanagi, Masaharu Ito, Ito M
Proteomics. Clinical applications · 2009 · vol. 3(10) , pp. 1201–1210 · doi:10.1002/prca.200900055 · PMID:21136944 · W2122883290
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This study identified anti-α-enolase autoantibody as a novel serum marker for endometriosis, comparable in sensitivity and specificity to CA125, and useful for improving diagnostic accuracy when used in combination.

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Abstract

Diagnosis of endometriosis needs invasive maneuvers. New serum marker that possesses both high sensitivity and high specificity has long been desired. To establish novel serum marker for endometriosis, serum autoantibodies (autoAbs) were investigated using proteomic approach. AutoAbs in sera of endometriotic patients and healthy controls were analyzed using a mesothelial cell line, 2-DE and Western blotting. Proteins in reacted spots were identified using MALDI TOF-MS with MASCOT analysis. ELISAs were established using recombinant proteins and autoAb-titers were estimated in sera of endometriotic patients, disease and healthy controls. Several autoAbs were identified. Anti-α-enolase (Eno1)-autoAb levels in endometriotic patients were significantly elevated compared with both healthy and disease controls. Sensitivity and specificity of serum anti-Eno1-autoAb was nearly comparable to serum CA125. When anti-Eno1-autoAb and CA125 assays were combined, diagnostic sensitivity and accuracy improved. Serum anti-Eno1-autoAb can be a new serum endometriotic marker and it is useful as a supplement assay for CA125. This study validates further clinical evaluation of this novel marker.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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