Effects of Lactobacillus gasseri OLL2809 on the induced endometriosis in rats

Masayuki Uchida, Uchida M, Kobayashi O, Orie Kobayashi
Bioscience, biotechnology, and biochemistry · 2013 · vol. 77(9) , pp. 1879–1881 · doi:10.1271/bbb.130319 · PMID:24018664 · W1971243464
Lab / animal OA: bronze CC0 ⤵ 22 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Lactobacillus gasseri OLL2809 administration significantly reduced induced endometriosis lesion volume in rats compared to controls, with complete healing observed in some subjects.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

We have reported an inhibitory effect of Lactobacillus gasseri OLL2809 (OLL2809) on the growth of mouse endometrial tissue in the abdominal cavity. The present study aimed to investigate the efficacy of Lactobacillus gasseri OLL2809 (OLL2809) on pre-existing endometriosis implanted on the abdominal wall in diestrus Wistar-Imamichi female rats. One week after implantation, the volume of the endometrial tissue was measured after laparotomy. OLL2809 and dienogest were administered for 4 weeks. OLL2809 significantly enhanced the decrease in the volume (p<0.01) as compared with control. Complete healing was observed in two of nine rats, but in none of the control group. Dienogest did not show significant efficacy. These findings suggest that OLL2809 is useful not only in therapy of pre-existing endometriosis but also in the prevention of the growth of endometrial tissue.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Lactobacillus Animals Animals Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Lactobacillus Lactobacillus Rats Rats Rats, Wistar

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (14)

Cited by (24)

Source provenance

europepmc
last seen: 2026-10-17T06:09:56.316927+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:12:29.265612+00:00
License: CC0 · commercial use OK