Multiple polypoid endometriosis--a rare complication following withdrawal of gonadotrophin releasing hormone (GnRH) agonist for severe endometriosis: a case report

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A 30-year-old female developed multiple, highly vascular endometrial polyps throughout her pelvic peritoneum and endometrium eight months after discontinuing GnRH agonist treatment for endometriosis.

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Abstract

A 30-year old female who initially had typical endometriosis treated according to a standard regimen later developed numerous highly vascular endometrial polyps on the vagina, cervix, ureter, serosal surfaces of the uterus, pouch of Douglas (POD) and other areas of pelvic peritoneum as well as the endometrium 8 months after withdrawal of treatment with Zoladex gonadotrophin releasing hormone (GnRH) agonist used for treatment of this disease. We postulate that these polyps developed as a rebound phenomenon upon withdrawal of Zoladex. We believe this is the first report of this complication following use of GnRH analogue.

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Condition tags

endometriosis

MeSH descriptors

Antineoplastic Agents, Hormonal Endometrial Neoplasms Endometriosis Gonadotropin-Releasing Hormone Goserelin Polyps Substance Withdrawal Syndrome Substance Withdrawal Syndrome Adult Adult Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (8)

Cited by (24)

Source provenance

europepmc
last seen: 2026-10-10T06:11:15.153948+00:00
openalex
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pubmed
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License: CC0 · commercial use OK