Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis

Jennifer F. Tseng, Tseng JF, J F Tseng, Ryan IP, I. P. Ryan, I. Ryan, Milam TD, T D Milam, Terry D. Milam, James T. Murai, J T Murai, Murai JT, Eldon D. Schriock, Schriock ED, E D Schriock, D V Landers, Landers DV, R N Taylor, Taylor RN, Robert N. Taylor
The Journal of clinical endocrinology and metabolism · 1996 · vol. 81(3) , pp. 1118–1122 · doi:10.1210/jcem.81.3.8772585 · PMID:8772585 · W1966113688
Lab / animal OA: bronze CC0 ⤵ 206 in-corpus citations
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Endometrial stromal cells from endometriosis implants, eutopic endometriosis tissue, and normal endometrium secreted IL-6 with higher concentrations in endometriosis tissues, especially when stimulated with IL-1 beta.

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Abstract

An in vitro model developed to compare human endometrial and endometriosis stromal cells was used to examine basal and stimulated expression of interleukin (IL-6). Stromal cells isolated from normal endometrium (NE) exhibited the lowest level of IL-6 secretion (84 pg/10(6) cells-48 h), whereas those cells isolated from endometriosis implants (EI) secreted the highest concentration of this inflammatory cytokine (46,284 pg/10(5) cells-48 h; P < 0.01). Eutopic endometrial stromal cells from women with endometriosis (EE) expressed an intermediate concentration of IL-6 (831 pg/10(6) cells-48 h). Stimulation of the various cultures with IL-1 beta dramatically augmented stromal cell production of IL-6. The mean concentrations of stimulated IL-6 secretion were 16,257, 37,800, and 264,290 pg/10(5) cells-48 h for NE, EE, and EI cells, respectively (P < 0.03). Exposure of the cell cultures to 10 nmol/L estradiol had little direct effect on IL-6 production. The results indicate that endometrial stromal cells isolated from tissues of women with and without endometriosis express IL-6 under basal and cytokine-stimulated conditions. Differential responsiveness among the three cell sources indicates that NE, EE, and EI cells have intrinsic quantitative differences in cytokine regulation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Interleukin-6 Stromal Cells Adult Adult Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Estradiol Estradiol Estradiol Female Female Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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