Fertility and sterility

OBJECTIVE: To analyze the expression of vascular endothelial growth factor A (VEGF-A) and receptors (VEGFR-1 and VEGFR-2) in endometrial blood vessels, as well as microvascular density (MVD), in endometrial biopsy samples from idiopathic me…

OBJECTIVE: To determine whether nonsteroidal antiinflammatory drugs (NSAIDs) affect the establishment and progression of endometriotic lesions in a murine model. DESIGN: Pharmacologic intervention in a surgically induced murine model of ab…

Tissue integrity of the regurgitated endometrium is pivotal to the development of endometriosis. Occult, submicroscopic lesions occur. Diagnostic laparoscopy may underestimate as well as overestimate the presence of endometriosis.

OBJECTIVE: To report two cases of orthotopic transplantation of fresh ovarian tissue. SETTING: Academic hospital. PATIENT(S): Two patients with severe endometriosis, who underwent left oophorectomy for recurrent endometriosis. INTERVENTI…

OBJECTIVE: To investigate the expression of oxytocin receptor (OTR) in peritoneal and ovarian endometriotic lesions. DESIGN: Retrospective nonrandomized study. SETTING: University hospital endometriosis research center. PATIENT(S): Preme…

OBJECTIVE: To determine whether oophorectomy during the perimenopause, with the associated decline in ovarian androgens, affects sexual function and psychological well-being negatively. DESIGN: Prospective, observational study comparing se…

OBJECTIVE: To induce apoptosis of endometriotic cells of patients with endometriosis. DESIGN: To demonstrate that polyglycolic acid/chitosan glue directly inhibits cell proliferation by inducing apoptosis. SETTING: University hospital inf…

The uterine, arcuate, and intraovarian blood flow measurements by transvaginal color doppler ultrasonography on the day of hCG injection in 46 women undergoing treatment by IVF at Aegean University Family Planning and Infertility Research a…

OBJECTIVE: To investigate whether and how P, dienogest (synthetic progestin), and danazol affected tumor necrosis factor alpha (TNFalpha)-induced interleukin-8 (IL-8) expression in endometriotic stromal cells. DESIGN: Prospective study. S…

OBJECTIVE: To determine whether menstrual cycle stage or activity has an effect on the clonogenic activity of human endometrial epithelial and stromal cells. DESIGN: Clonal analysis of human endometrial epithelial and stromal cells derived…

OBJECTIVE: To characterize sexual function among women with endometriosis and deep dyspareunia (DD). DESIGN: Cross-sectional survey. SETTING: University teaching hospital. PATIENT(S): Three-hundred nine women undergoing surgery because o…

OBJECTIVE: To investigate quantitative aberrations involving p53 copy numbers in eutopic endometrial and endometriotic tissue from two populations. DESIGN: Comparative analysis of normal and diseased tissue. SETTING: Tissue specimens coll…

OBJECTIVE: To analyze endometrial progesterone receptor (PR) expression in women with endometriosis compared with disease-free women and to assess the impact of in vitro 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on PR isotype expr…

OBJECTIVE: To discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis. DESIGN: A review of experimental evidence regarding the failure of P to regulate the expression …

OBJECTIVE: To examine the effect of interleukin-6 (IL-6) on estrogen production and aromatase activity using a human granulosa tumor cell line (KGN cells). The involvement of the mitogen-activated protein kinase (MAPK) cascade in the inhibi…

OBJECTIVE: To determine whether Oxiplex/AP Gel (FzioMed, San Luis Obispo, CA) was safe and preliminarily effective in reducing postsurgical adhesions after adnexal surgery by laparoscopy. DESIGN: Prospective, multicenter, double-blind, ran…

OBJECTIVE: Endometriosis may originate from implants of endometrium due to retrograde flow of menstrual blood. The flow may be stimulated by anatomical anomalies of uterine tubes or uterus. The aim of the study was to find links between ana…

OBJECTIVE: To report our experience in patients with previous IVF failures who conceived after laparoscopic treatment of endometriosis. DESIGN: Retrospective case series. SETTING: Tertiary center IVF and endoscopy programs. PATIENT(S): I…

In the present nonrandomized pilot study we determined the role of the vaginally administered aromatase inhibitor anastrozole (0.25 mg anastrozole/d for 6 months) in the treatment of women with histologically proven rectovaginal endometrios…

OBJECTIVE: To report a case of sciatic endometriosis diagnosed by computerized tomography (CT)-guided biopsy in combination with CD10 immunohistochemical staining. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 33-year-…

OBJECTIVE: To determine and compare levels of levonorgestrel (Lng) in serum and peritoneal fluid (PF) of patients on the Lng intrauterine system Mirena (Schering Health, Berlin, Germany) for endometriosis and to relate these to symptoms. D…

OBJECTIVE: To examine stress physiology and facts of family functioning associated with development and course of endometriosis symptoms. DESIGN: Clinical case data and literature review. SETTING: Private practice in hospital-affiliated m…

OBJECTIVE: To investigate the localization and expression of steroid sulfatase (STS) in cumulus cells obtained from subjects with and without endometriosis. DESIGN: Case-control study. SETTING: In vitro fertilization program at the Showa …

OBJECTIVE: To use power Doppler ultrasound to assess the effect of endometriosis on intraendometrial and subendometrial blood flow during the menstrual cycle. DESIGN: An observational prospective study. SETTING: Academic teaching hospital…