Yan Li

This study aimed to induce malignant transformation of endometriosis in Sprague-Dawley rats by hyperestrogenemia and type II diabetes and evaluate its similarity with human disease in biological features. Rats with surgically induced endome…

Ovarian endometrioma is a common form of endometriosis, which may cause infertility, dysmenorrhea and pelvic pain in women of reproductive age. Although surgery is the treatment of choice for endometriomas, recurrence poses a formidable fru…

The aim of the present study was to investigate the role of epigenetic inactivation of the runt-related transcription factor 3 gene (RUNX3) in the malignant transformation of ovarian endometriosis. Samples obtained by microdissection and sc…

Clear cell adenocarcinoma (CCC) of the ovary accounts for 10% of epithelial ovarian cancer and is a distinct entity from other epithelial ovarian carcinomas. It arises from the endometriosis. CCC has specific biological and clinical behavio…

AIM: To investigate the association of tag single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor receptor 2 (VEGFR-2) gene with susceptibility to endometriosis. METHODS: This study comprised 571 patients with endo…

OBJECTIVE: To assess the association between single nucleotide polymorphisms (SNPs) of forkhead box P3 gene (FOXP3) and endometriosis in Chinese Han women from central China. METHODS: MassARRAY IPLEX and matrix-assisted laser desorption/ion…

Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis

Platelet-derived growth factor (PDGF) is well known to induce proliferation in variety of cells. The aim of this study was to investigate whether there is a correlation between the expression of Cofilin-1 (CFL1) and the proliferation of eut…

Endometriosis is a steroid-dependent complex disease. The oestrogen receptor plays an important role by mediating oestrogen action and eutopic or ectopic endometrium development. This study investigated whether single-nucleotide polymorphis…

目的探讨整合素B1（Intβ1）、基质金属蛋白酶-2（MMP-2）及促肝细胞再生磷酸酶．3（PRL．3）在子宫内膜异位症（EMS）中的表达。方法选取EMS患者异位内膜30例、在位内膜20例和子宫肌瘤患者非瘤区子宫内膜组织20例（对照内膜），应用免疫组织化学方法检测各组织中Intβ1、MMP-2及PRL-3的表达水平。结果Intβ1、MMP-2和PRL-3在异位内膜中的表达明显高于在位内膜和对照内膜（P均〈0．01）。在对照内膜分泌期Intβ1表达强于增生期（P〈0．05）；在…

Objective:To give some new theoretical basis and treatment methods for different individual of EMs,not only to discuss the differences appearing in different individual endometrial in uPAR and LN,but also to discuss the differences may have…

BACKGROUND: Adenomyosis is a common gynecological disease, which is accompanied by a series of immunological and neuroendocrinological changes. Nerve growth factor (NGF) plays a critical role in producing pain, neural plasticity, immunocyte…

BACKGROUND: Angiogenesis appears to be an important event in the pathophysiology of endometriosis (EM) and adenomyosis. Two angiogenic factors, fibroblast growth factor (FGF) 1 and 2, play a central role in the initiation of angiogenesis. W…

Objective: To explore the clinical application of hysteroscopy combined with laparoscopy in diagnosis and treatment of chronic pelvic pain ( CPP) . Methods: 80 patients with CPP were diagnosed and treated by laparoscopy and hysteroscopy,ult…

BACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in the development of endometriosis. The aim of this study was to investigate the association of polymorphisms in the VEGF gene with the susceptibility to endomet…

OBJECTIVE: To investigate the association of single nucleotide polymorphisms (SNPs) in VEGF gene with the risk of endometriosis and adenomyosis. METHODS: Genotypes were analyzed by polymerase chain reaction-restriction fragment length polym…

子宫内膜异位症(内异症)和子宫腺肌病(腺肌病)为妇科常见疾病,但其病因及发病机制尚不明确.虽为良性疾病,但具有周围浸润、远处转移和种植的恶性行为,其中血管生成在子宫内膜异位种植的过程中起重要作用。

Vascular endothelial growth factor (VEGF), a major mediator of angiogenesis and vascular permeability, may play a key role in the development of adenomyosis. The aim of this study was to investigate whether these four VEGF polymorphisms (-2…

We investigated whether three polymorphisms in the matrix metalloproteinase-2 (MMP-2; -1306C-->T and -735C-->T) and tissue inhibitor of metalloproteinase-2 (TIMP-2; -418G-->C) genes were related to the risk of endometriosis in reproductive-…

Objective To investigate the expression of transforming growth factor-β1(TGF-β1)and matrix metalloproteinase-2(MMP-2) in the ectopic endometrium of adenomyoma and their relation with the pathogenesis of adenomyoma.Methods Endometrial specim…

The matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may contribute to the development of adenomyosis. The aim of the present study was to investigate whether three single nucleotide polymorphisms (SNPs) i…

OBJECTIVE: To investigate the association of single nucleotide polymorphisms (SNPs) in matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) with the risk of endometriosis and adenomyosis. METHODS: Genotype…

Objective To measure the levels of prostaglandins(PGE2,TXB2)in biopsy specimens from patients with endometriosis,and explore the relationship between prostaglandin level and the severity of pain.Methods The expression of PGE2,TXB2 protein w…