Xinmei Zhang

OBJECTIVE: To determine whether nerve fibers can be detected in the endometrium and myometrium in women with painful uterine fibroids and adenomyosis. DESIGN: A retrospective immunohistochemical study. SETTING: An academic training hospit…

OBJECTIVE: To evaluate the quality of literatures and the accuracy of ultrasonography in diagnosis of deeply infiltrating endometriosis (DIE). METHODS: The database of Medline (1966 to 2009), the excerpta medica database (EMBASE, 1980 to 20…

ObjectiveTo investigate the expression of phosphatase of regenerating liver-3 (PRL-3) in ectopic, eutopic, and normal endometria and explore its relationship with endometriosis.DesignA clinical retrospective and molecular study.SettingDepar…

OBJECTIVE: To investigate the association between distribution of protein gene product (PGP) 9.5-immunoactive nerve fibers in peritoneal endometriotic lesions and disease-associated pain symptoms. METHODS: Thirty two peritoneal endometrioti…

Objective To investigate whether IL-10 gene promoter polymorphisms are associated with IL-10 protein production in serum and peritoneal fluid and endometriosis risk in Chinese people. Methods Genomic DNA was extracted from blood lymphocytes…

OBJECTIVE: To investigate nerve fibers distribution in endometrium of adenomyosis and their relationship with dysmenorrhea. METHODS: Endometrial tissue was sampled from 74 hysterectomy specimens including 32 cases with adenomyosis and 42 ca…

fibroids To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with…

To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with uterine …

BACKGROUND: Although nerve fibres are present in eutopic and ectopic endometrium, it is unclear whether they appear in ovarian endometriotic lesions. We investigated the presence of nerve fibres in ovarian endometriotic lesions and its corr…

OBJECTIVE: To investigate the metabolism of lipid, calcium and phosphorus in women with endometriosis. METHODS: Clinical data of 223 patients with endometriosis and 200 patients without endometriosis were retrospectively analyzed. Electroch…

BACKGROUND: Danazol, a synthetic steroid with antigonadotrophic properties, has been widely used for the treatment of endometriosis and adenomyosis. However, the local application of danazol to the uterus to treat adenomyosis is controversi…

OBJECTIVE: To determine the level of interleukin-1 receptor antagonist (IL-1ra) in peritoneal fluid (PF) and serum in patients with endometriosis. DESIGN: A prospective analytical study. SETTING: University-affiliated obstetrics and gynec…

ObjectiveTo assess the concentrations of interleukin-15 (IL-15) in peritoneal fluid from women with endometriosis and fertile disease-free controls.Study designPeritoneal fluid samples were obtained from 50 women with endometriosis and 29 f…

OBJECTIVE: To investigate whether interleukin-1 beta (IL-1beta ) and interleukin-1 receptor antagonist (IL-1RA) gene polymorphisms are associated with endometriosis (EMs) in Chinese women. METHODS: One hundred and thirty-eight patients with…

Objective To analyze whether the expression level of interleukin-1 receptor antagonist(IL-1Ra) or gene polymorphism of IL-1Ra is associated with endometriosis(EMs).Methods Blood sample and peritoneal fluid were collected from 138 patients w…

OBJECTIVE: To investigate the role of interleukin-17 (IL-17) in the pathogenesis of endometriosis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of IL-17 in peritoneal fluid of 36 patients with dif…

OBJECTIVE: To investigate the role of interleukine-16 (IL-16) in the pathogenesis of endometriosis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of IL-16 in peritoneal fluid and serum specimens of 22 w…

Interleukin-16 (IL-16) is a homotetramer of 14-kDa subunits discovered in 1982 as a T-cell-specific chemoattractant factor. The gene of IL-16 is located on chromosome 15 (15q26.1) and unrelated to other interleukins or chemokines (1). IL-16…

This prospective study aimed to determine whether patients with endometriosis are having different level of interlukin-17 (IL-17) in peritoneal fluid when compared with patients without endometriosis. The patients with minimal/mild endometr…

ObjectiveTo determine the concentrations of interleukin-18 (IL-18) in peritoneal fluid and serum in patients with endometriosis in comparison with the control group.DesignA prospective analytical study.SettingThe obstetrics and gynecology d…

Endometriosis is a common gynecologic problem and its etiology is unknown. More and more animal experiments and environmental epidemiological studies suggested that environmental toxins such as dioxin seemed to play an important role in pat…

OBJECTIVE: To investigate the correlation between glutathione S-transferase (GST) M1 and T1 genotypes and endometriosis risk (EM). METHODS: Polymerase chain reaction (PCR) technique was used to detect the presence or absence of the GSTM1 an…