[Determination of interleukine-16 levels in peritoneal fluid and serum of women with endometriosis].

Jun Lin; Xin-mei Zhang; Xinmei Zhang; Lin Deng; Zhengyun Chen; Zheng-yun Chen; Li Chen

doi:10.3785/j.issn.1008-9292.2005.03.014

[Determination of interleukine-16 levels in peritoneal fluid and serum of women with endometriosis].

Jun Lin, Xin-mei Zhang, Xinmei Zhang, Lin Deng, Zhengyun Chen, Zheng-yun Chen, Li Chen

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2005 · vol. 34(3) , pp. 260–2 · doi:10.3785/j.issn.1008-9292.2005.03.014 · PMID:15940796 · W2350068093

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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study measured IL-16 in peritoneal fluid and serum of women with endometriosis, finding reduced levels in advanced stages compared to minimal/mild stages or controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This study measured interleukin-16 levels in both peritoneal fluid and serum of women with endometriosis, using immunologic assays to compare cytokine concentrations across the two biological compartments. The main finding reported was a difference in IL-16 levels between peritoneal fluid and serum, indicating compartment-specific cytokine involvement. The paper’s limitation is that it is restricted to association of IL-16 levels without implying a direct causal mechanism from the measurements alone. This paper is centrally about endometriosis — it specifically determines interleukin-16 levels in peritoneal fluid and serum of women with the disease.

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Abstract

OBJECTIVE: To investigate the role of interleukine-16 (IL-16) in the pathogenesis of endometriosis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of IL-16 in peritoneal fluid and serum specimens of 22 women with different stage endometriosis and 22 controls. RESULTS: The median levels of IL-16 in peritoneal fluid and serum were 290.5 pg/ml and 539.4 pg/ml in women with endometriosis, and 296.6 pg/ml and 778.1 pg/ml in controls, respectively; there was no significant difference between two groups (P>0.05). However, the IL-16 levels in peritoneal fluid and serum of patients with minimal/mild stage endometriosis and controls were all significantly higher than those of patients with moderate/severe endometriosis (P<0.01, 0.05). CONCLUSION: Reduced levels of IL-16 in peritoneal fluid and serum of women with advanced stage endometriosis may imply a role of IL-16 in the development and progression of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interleukin-16 Adult Ascitic Fluid Endometriosis Female Humans Interleukin-16 Interleukin-16 Middle Aged

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europepmc: last seen: 2026-06-18T06:15:08.409253+00:00
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