Yutaka Osuga

Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR₁ and PAR₂ are expressed in endometrial cells from the eutopi…

Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR1 and PAR2 are expressed in endometrial cells from the eutopi…

Laparoscopic excision is considered as the 'gold standard' treatment of ovarian endometrioma. However, a frustrating aspect is that disease can recur. While laparoscopic excision is known to improve fertility, recurrence can cause significa…

ObjectiveTo examine the regulation and the function of activin-A in stromal cells derived from endometrioma.DesignMolecular studies.SettingUniversity research laboratory.Patient(s)Endometrioma stromal cells (EoSC) were obtained from 28 pati…

Extragenital endometriosis severely impairs the quality of life for affected women but its standard management has not yet been well established because of its relatively low incidence. As extragenital organs, intestine, followed by urinary…

ObjectiveTo examine the effects of interleukin (IL)-17F on the secretion of IL-8 and the gene expression of cyclooxygenase 2 (COX2) in endometriotic stromal cells.DesignIn vitro experimental study using human samples.SettingUniversity hospi…

Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR1 and PAR2 are expressed in endometrial cells from the eutopi…

BACKGROUND: Proteinase-activated receptor 2 (PAR2) is a G-protein-coupled receptor that is activated by several serine proteases. PAR2 activation in endometriotic stromal cells (ESCs) has been implicated in the development of endometriosis …

Objective: The efficacy of diagnostic laparoscopy should be re-considered due to the improved success rate of assisted reproductive technologies (ART). Methods: We retrospectively reviewed clinical records of 126 women who were examined by …

Endometriosis is a disease that causes the health of women of reproductive age to deteriorate. The implantation theory is the most widely accepted pathogenesis of the disease, although many points remain poorly understood concerning this th…

In an animal endometriosis model, the administration of hyaluronic acid (HA) reagent significantly suppressed the formation of endometriotic lesions in both number and weight. This effect was found when HA treatment was conducted at the tim…

Endometriosis is a disease characterized by the presence of endometriotic tissue outside the uterine cavity. Although its pathogenesis remains to be elucidated, immune status is suggested to play an important role in the initiation and the …

Introduction: Endometriosis, defined as the growth of endometrial tissue outside \nthe uterine cavity is a common gynaecological disorder affecting 10-15% \nof women in their reproductive years. It is a major clinical problem causing in- \n…

BACKGROUND: Regulation of decidualization is decisive for proper implantation and the establishment of pregnancy. Recent studies have suggested that several bone morphogenetic proteins (BMPs) play physiological roles in reproduction. In the…

In a novel paradigm of T cell differentiation, type 17 T helper (Th17) cells may play a significant role in endometriosis, a chronic inflammatory disease. However, the mechanism regulating the accumulation of Th17 cells in endometriotic tis…

OBJECTIVE: To determine possible involvement of splice variant 1 (SV1), a variant of the pituitary growth hormone-releasing hormone (GHRH) receptor, in the development of endometriosis. DESIGN: Comparative and laboratory study. SETTING: U…

ObjectiveTo study the relationship between eotaxin and interleukin-4 (IL-4) in the pathophysiology of endometriosis.DesignComparative and laboratory study.SettingUniversity teaching hospital reproductive endocrinology and infertility practi…

BACKGROUND: The aim of this study was to evaluate the impact of post-operative oral contraceptives (OCs) use on the rate of recurrence after laparoscopic excision of ovarian endometrioma. METHODS: In May 2005, we introduced a 'post-operativ…

Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases such as trypsin, tryptase, and coagulation factors VIIa and Xa. A large body of evidence has shown that PAR2 plays an important rol…

During the menstrual cycle, dynamic morphological changes are observed in the ovarian follicle and the endometrium. These changes are associated with the onset of the inflammatory response in which many proteinases play various roles. Throm…

Endometriosis is a common gynecological disease that affects approximately 10% of women of childbearing age. It is characterized by endometrial growth outside the uterus and often results in inflamed lesions, pain, and reduced fertility. Al…

Several lines of evidence indicate that the Th2 immune response is associated with endometriosis. Although an increased concentration of interleukin (IL)-4, a typical Th2 cytokine, has been reported in endometriotic tissues, the implication…

It has previously been considered that the therapeutic effects of gonadotropin-releasing hormone (GnRH) analogues on endometriosis could be explained by the suppression of estrogen levels due to pituitary downregulation; however, recent res…