Anna Starzinski-Powitz

No ORCID on file · 28 papers in corpus · active 2003-2018

Study types

  • article 19
  • other 7
  • review 2

Condition tags

  • mesh:D004715 22
  • endometriosis 17
  • infertility 2
  • dysmenorrhea 1
  • mesh:D017699 1
  • die_deep_infiltrating 1
article 2018
Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells
Biochimica et biophysica acta. Molecular and cell biology of lipids ·doi:10.1016/j.bbalip.2018.08.013
review 2017
Molecular and Cellular Pathogenesis of Endometriosis
Current women's health reviews ·doi:10.2174/1573404813666170306163448

BACKGROUND: A substantial body of studies supports the view that molecular and cellular features of endometriotic lesions differ from those of eutopic endometrium. Apart from that, evidence exists that the eutopic endometrium from pa-tients…

article 2016
microRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2015.12.013
article 2016
PAI-1 secretion of endometrial and endometriotic cells is Smad2/3- and ERK1/2-dependent and influences cell adhesion
American journal of translational research ·doi:10.22029/jlupub-8634

In the endometrium transforming growth factor-betas (TGF-βs) are involved mainly in menstruation and endometriosis. After binding of the ligands to the high-affinity receptors, TGF-β receptors (TBR1 and TBR2), TGF-βs activate Smad signaling…

article 2016
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells

Endometriosis is a chronic gynecological disease of reproduc-tive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. Interactions between the endometriotic cells and the peritoneal extracel…

article 2016
Syndecan-4 expression is upregulated in endometriosis and contributes to an invasive phenotype
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.03.032
article 2015
Molecular and preclinical basis to inhibit PGE 2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1507931112

Endometriosis is a debilitating, estrogen-dependent, progesterone-resistant, inflammatory gynecological disease of reproductive age women. Two major clinical symptoms of endometriosis are chronic intolerable pelvic pain and subfertility or …

article 2015
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2015.03.023
other 2014
Novel three-dimensional in vitro models of ovarian endometriosis
Journal of ovarian research ·doi:10.1186/1757-2215-7-17

BACKGROUND: Endometriosis is characterized by the presence of functional endometrial tissue outside of the uterine cavity. It affects 1 in 10 women of reproductive age. This chronic condition commonly leads to consequences such as pelvic pa…

other 2013
MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.11.055

OBJECTIVE: To study the function of miR-145, known to be dysregulated in endometriosis, and to identify its target genes in an in vitro endometriosis model. DESIGN: Experimental laboratory study. SETTING: University medical centers. PATI…

article 2012
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Inhibits Adhesion of Human Endometriotic Epithelial and Stromal Cells Through Suppression of Integrin-Mediated Mechanisms1
Biology of reproduction ·doi:10.1095/biolreprod.112.100883

Endometriosis is a chronic gynecological disease of reproductive age women characterized by the presence of functional endometrial tissues outside the uterine cavity. Interactions between the endometriotic cells and the peritoneal extracell…

article 2012
Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.10.051
article 2010
Constitutive and Tumor Necrosis Factor-Alpha-Stimulated Activation of Nuclear Factor-KappaB in Immortalized Endometriotic Cells and Their Suppression by Trichostatin A
Gynecologic and obstetric investigation ·doi:10.1159/000279324

OBJECTIVE(S): To determine whether nuclear factor-kappaB (NF-kappaB) is constitutively and tumor necrosis factor (TNF)-dependently activated in endometriotic cells, whether trichostatin A (TSA) can suppress NF-kappaB activation and suppress…

other 2010
Inhibition of cell proliferation, adhesion, and invasion with an anti-L1-cell adhesion molecule monoclonal antibody in an in vitro endometriosis model
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.11.050

The use of anti-L1-cell adhesion molecule monoclonal antibodies (anti-L1CAM-mAb) in an endometriosis epithelial cell line Z12 led to a statistically significant decrease in cell proliferation and cell invasion and to an inhibition of the ad…

other 2010
Selective blockade of prostaglandin E2 receptors EP2 and EP4 signaling inhibits proliferation of human endometriotic epithelial cells and stromal cells through distinct cell cycle arrest
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.01.038

OBJECTIVE: To determine interactions between prostaglandin (PG) E(2) signaling and proliferation of endometriotic cells to increase our knowledge about PGE(2) signaling in the pathogenesis of endometriosis in humans. DESIGN: Immortalized h…

article 2010
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2010.11.022
article 2009
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2009-0017

Endometriosis is a benign chronic gynecological disease of reproductive-age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities …

article 2008
Capsaicin Inhibits Proliferation of Endometriotic Cells in vitro
Gynecologic and obstetric investigation ·doi:10.1159/000124275

Treatment of immortalized stromal-like and epithelial-like endometriotic cells with capsaicin resulted in inhibition of proliferation in a concentration-dependent manner. In addition, endometriotic cells are more sensitive to capsaicin trea…

article 2008
Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.06.050
other 2008
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
Molecular pharmacology ·doi:10.1124/mol.107.042176

Tumor necrosis factor (TNF)-alpha is central to the endometriotic disease process. TNF-alpha receptor signaling regulates epithelial cell secretion of inflammation and invasion mediators. Because epithelial cells are a disease-inducing comp…

article 2007
Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.07.1358
other 2007
Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147
Molecular biology of the cell ·doi:10.1091/mbc.e06-07-0637

Shrew-1 was previously isolated from an endometriotic cell line in our search for invasion-associated genes. It proved to be a membrane protein that targets to the basolateral membrane of polarized epithelial cells, interacting with E-cadhe…

article 2007
Prolonged stimulation with tumor necrosis factor-α induced partial methylation at PR-B promoter in immortalized epithelial-like endometriotic cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.06.008
article 2007
Trichostatin A, a Histone Deacetylase Inhibitor, Attenuates Invasiveness and Reactivates E-Cadherin Expression in Immortalized Endometriotic Cells
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719107302913
article 2005
Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.11.038