The influence of infertility etiology on the outcome of IVF-ET and GIFT treatments

J L Yovich, John L. Yovich, Yovich JL, Matson PL, Phillip Matson, P L Matson
International journal of fertility · 1990 · vol. 35(1) , pp. 26–33 · PMID:1968441 · W2413819332
Observational OA: closed CC0 ⤵ 19 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study found that infertility etiology impacts IVF-ET and GIFT success, with GIFT offering better pregnancy rates, especially for severe endometriosis, and requiring increased insemination for oligospermia.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The present report examines retrospectively the success rates of both in-vitro fertilization and embryo transfer (IVF-ET) and gamete intrafallopian transfer (GIFT) in relation to the underlying infertility disorder. Reduced fertilization rates were seen when the male partner was oligospermic or had both IgA and IgG in his semen, or the female partner had elevated LH concentrations during the follicular phase. In IVF-ET, the chance of pregnancy was reduced in women with elevated LH concentrations or endometriosis. Pregnancy rates for patients treated in the GIFT program were significantly better (P less than .001) than for those treated by IVF-ET. Of special interest was the finding of an improved chance of pregnancy for patients with severe endometriosis treated by GIFT (P less than .001). With oligospermia, pregnancies were only achieved in the GIFT program when the insemination number was increased. The pregnancy outcome was similar in both programs, with approximately 70% of pregnancies delivering beyond 20 weeks' gestation. However, there was a high rate of ectopic pregnancy, particularly in cases with underlying tubal disease. These findings have led to revised guidelines for the accurate counseling of patients, and provide further insight into the possible mechanism of various disorders contributing to infertility.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Embryo Transfer Endometriosis Fertilization in Vitro Gamete Intrafallopian Transfer Gamete Intrafallopian Transfer Infertility, Female Oligospermia Oligospermia Oligospermia Adult Adult Embryo Transfer Embryo Transfer Endometriosis Endometriosis Endometriosis Endometriosis Female Female Fertilization in Vitro

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (18)

Source provenance

europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:06:50.232585+00:00
License: CC0 · commercial use OK