Circular RNA expression in ovarian endometriosis

Shen L, Licong Shen, Yu Zhang, Wenjun Zhou, Zhou W, Peng Zheng, Peng Z, Zheng Peng, Xiaxia Hong, Hong X, Zhang Y, Yi Zhang
Epigenomics · 2018 · vol. 10(5) , pp. 559–572 · doi:10.2217/epi-2017-0079 · PMID:29334789 · W2782607110
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This study identified 262 upregulated and 291 downregulated circRNAs in ovarian endometriosis compared to normal endometrium, forming a ceRNA network involved in nine biological pathways.

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Abstract

AIM: Circular RNAs (circRNAs) with miRNA response elements (MREs) could function as competing endogenous RNA (ceRNA) in regulating gene expression. This study was carried out to identify the expression profile and role of circRNAs in endometriosis. MATERIALS & METHODS: Microarray assay was performed in four paired ovarian endometriomas and eutopic endometrium, followed by quantitative real-time RT-PCR in 24 paired samples. Bioinformatical algorithms were used to predict MREs, as well as ceRNA and KEGG pathway analysis. RESULTS: We identified 262 upregulated and 291 downregulated circRNAs, binding with 1225 MREs. The ceRNA network included 122 miRNAs and 137 mRNAs, which are involed in nine pathways. CONCLUSION: CircRNAs are differentially expressed in endometriosis, which might be related with pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Expression Regulation Gene Expression Regulation MicroRNAs Ovary RNA Adult Adult Down-Regulation Down-Regulation Endometriosis Endometriosis Female Female Gene Expression Profiling Gene Expression Profiling Humans Humans MicroRNAs MicroRNAs

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (42)

Cited by (14)

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