Effect of alpha-lipoic acid on endometrial implants in an experimental rat model

Neslihan Pınar, Soylu Karapınar O, Oya Soylu Karapınar, Oğuzhan Özcan, Tümay Özgür, Özgür T, Suphi Bayraktar, Bayraktar S
Fundamental & clinical pharmacology · 2017 · vol. 31(5) , pp. 506–512 · doi:10.1111/fcp.12293 · PMID:28429826 · W2605964278
Lab / animal OA: closed CC0 ⤵ 9 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Alpha-lipoic acid treatment in rats significantly reduced endometrial implant volume, inflammatory markers, and oxidative stress compared to saline, suggesting a therapeutic potential for endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

To investigate the antioxidant and anti-inflammatory effects of alpha-lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre- and post-treatment. Tumor necrosis factor alpha (TNF-α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF-α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha-lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti-inflammatory effects.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Antioxidants Autografts Disease Models, Animal Disease Models, Animal Endometriosis Endometrium Thioctic Acid Animals Animals Antioxidants Antioxidants Antioxidants Autografts Autografts Autografts Endometriosis Endometriosis Endometriosis Endometriosis Endometrium

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (42)

Cited by (9)

Source provenance

europepmc
last seen: 2026-10-12T06:17:10.165071+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:19:42.633400+00:00
License: CC0 · commercial use OK