The "treatment" of unexplained infertility with danazol

Jacoba G. Van Dljk, J G van Dijk, M Frŏlich, Marijke Frölich, Egenius C. Brand, E C Brand, E V van Hall, Eylard V. van Hall
Fertility and sterility · 1979 · vol. 31(5) , pp. 481–485 · doi:10.1016/s0015-0282(16)43989-0 · PMID:376355 · W2415973458
RCT OA: closed CC0 ⤵ 12 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper investigated the efficacy of danazol treatment for unexplained infertility, reporting on its outcomes and clinical implications.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

In order to investigate the possible stimulating effect of danazol on fertility, a randomized clinical trial was performed on 40 women with unexplained infertility. Of these 40 women, 21 received 200 mg of danazol daily for 100 days and 19 received a placebo treatment during the same period. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, estrone, estradiol, progesterone, and testosterone were followed before, during, and after treatment. Danazol administration induced anovulation in all women, with prompt resumption of normal ovulatory function after discontinuation of the drug. No influence was seen on serum LH, FSH, and testosterone levels, but serum estrone, estradiol, and progesterone levels decreased significantly during treatment. Serum prolactin levels also decreased, but not significantly. No pregnancies occurred in the placebo group during a 6-month follow-up period. In the danazol group, five pregnancies occurred, of which two were ectopic and three went to term. The difference in pregnancy rate between both groups was statistically significant (P less than 0.05).

My notes (saved in your browser only)

Condition tags

infertility

MeSH descriptors

Danazol Infertility, Female Pregnadienes Adult Clinical Trials as Topic Danazol Female Follow-Up Studies Humans Infertility, Female Placebos Pregnadienes Prolactin Prolactin

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (12)

Source provenance

openalex
last seen: 2026-05-14T06:18:49.133728+00:00
pubmed
last seen: 2026-10-08T21:41:06.236526+00:00
License: CC0 · commercial use OK