Danazol for unexplained infertility
review
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⤵ 1 in-corpus citation
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Two randomized trials involving 68 women found no difference in pregnancy rates between danazol and placebo for unexplained infertility, indicating insufficient evidence for its efficacy.
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Abstract
BACKGROUND: The androgen, Danazol, was developed in the 1970's as a treatment for endometriosis. Its use was soon advocated in women with unexplained infertility. Two randomized trials were subsequently conducted to assess the effectiveness of danazol in this population. OBJECTIVES: The objective of this review was to assess the effects of danazol on pregnancy rates in women with unexplained subfertility. SEARCH STRATEGY: The Cochrane Subfertility Review Group specialised register of controlled trials was searched. SELECTION CRITERIA: Randomised trials of danazol compared with placebo or no treatment in women with unexplained subfertility. DATA COLLECTION AND ANALYSIS: Data were extracted by two reviewers. MAIN RESULTS: Two trials involving 68 women were involved. There was no difference found in pregnancy rate between danazol and placebo (odds ratio 2.57, 95% confidence 0.53 to 12.46). REVIEWER'S CONCLUSIONS: There is not enough evidence to evaluate the effect of danazol on pregnancy rates in women with unexplained subfertility. The need to use contraception during danazol treatment, adverse effects and costs are additional considerations.
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Too few in-corpus citations on either side for a chart; here are the lists.
Cites (4)
- Experiences with Danazol (an antigonadotropin) in the treatment of infertility 1974
- The “Treatment” of Unexplained Infertility with Danazol 1979
- Danazol in the Treatment of Menorrhagia: The Effect of a 1 Month Induction Dose (200 mg) and 2 Month's Maintenance Therapy (200 mg, 100 mg, 50 mg or placebo) 1992
- Is danazol a useful treatment in unexplained primary infertility? 1989
Cited by (1)
References (4)
- Danazol in the Treatment of Menorrhagia: The Effect of a 1 Month Induction Dose (200 mg) and 2 Month's Maintenance Therapy (200 mg, 100 mg, 50 mg or placebo) via openalex
- Experiences with Danazol (an antigonadotropin) in the treatment of infertility via openalex
- Is danazol a useful treatment in unexplained primary infertility? via openalex
- The “Treatment” of Unexplained Infertility with Danazol via openalex
Cited by (1)
Source provenance
- europepmc
- last seen: 2026-06-13T06:22:48.782012+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:13:41.710148+00:00
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