The Genetic Epidemiology of Spontaneous Endometriosis in the Rhesus Monkey

Krina Zondervan, Krina T. Zondervan, Cardon L, L. R. Cardon, Lon Cardon, Desrosiers R, Ronald Desrosiers, Ronald C. Desrosiers, Hyde D, Dallas Hyde, Dallas M. Hyde, Joseph W. Kemnitz, Joseph Kemnitz, Keith Mansfield, Keith G. Mansfield, Mansfield K, JEFF ROBERTS, Roberts J, J. Scheffler, Joan Scheffler, Scheffler J, Daniel E. Weeks, Kennedy S, Stephen Kennedy
Annals of the New York Academy of Sciences · 2002 · vol. 955(1) , pp. 233–238 · doi:10.1111/j.1749-6632.2002.tb02784.x · PMID:11949951 · W2133218876
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Spontaneously occurring endometriosis in rhesus monkeys offers a valuable animal model for investigating the complex genetic epidemiology of this disease due to anatomical and physiological similarities with humans.

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Abstract

The etiology of endometriosis is uncertain, but there is increasing evidence that it is inherited as a complex genetic trait like diabetes or asthma. In such complex traits, multiple gene loci conferring susceptibility to the disease interact with each other and the environment to produce the phenotype. The study of such interactions in humans can be problematic. Thus, the availability of an animal model, which shares many aspects of anatomy and physiology with humans, is potentially a valuable tool for investigating the genetic epidemiology of the disease. Since endometriosis develops spontaneously in the rhesus monkey (Macaca mulatta) and the tissue is morphologically identical to its human counterpart, this population provides a unique opportunity to conduct such studies in this condition.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Molecular Epidemiology Animals Disease Models, Animal Endometriosis Endometriosis Female Macaca mulatta

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (19)

Cited by (23)

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