Neutrophil recruitment and function in endometriosis patients and a syngeneic murine model

Symons LK, Lindsey K. Symons, Miller JE, Jessica E. Miller, Kathrin Tyryshkin, Tyryshkin K, Monsanto SP, Stephany P. Monsanto, Ryan M. Marks, Marks RM, Harshavardhan Lingegowda, Vanderbeck K, Kaitlin Vanderbeck, Childs T, Timothy Childs, Steven L. Young, Bruce A. Lessey, Lessey BA, Koti M, Madhuri Koti, Tayade C, Chandrakant Tayade
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019 · vol. 34(1) , pp. 1558–1575 · doi:10.1096/fj.201902272r · PMID:31914688 · W2992652511
Lab / animal OA: closed CC0 ⤵ 45 in-corpus citations
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This study characterized neutrophils in endometriosis patients and a mouse model, finding they reside in lesions, exhibit transcriptomic differences in patients, and influence the peritoneal immune microenvironment and angiogenesis early in the disease.

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Abstract

Endometriosis is a chronic inflammatory, gynecological disease characterized by the presence of endometrial-like tissue lesions outside of the uterus. Neutrophils are elevated in the systemic circulation and peritoneal fluid of endometriosis patients; however, whether and how neutrophils contribute to endometriosis pathophysiology remain poorly understood. With emerging roles for neutrophils in chronic and sterile inflammatory conditions, we sought to provide in-depth characterization of neutrophil involvement in endometriosis. We demonstrate that neutrophils reside within patient endometriotic lesions and that patient lesions possess a microenvironment that may influence neutrophil recruitment and function. We also provide the first evidence that systemic circulating neutrophils from endometriosis patients display distinct transcriptomic differences compared neutrophils from healthy control subjects. Time course characterization of our syngeneic, immunocompetent mouse model of endometriosis revealed that neutrophils are rapidly recruited to the peritoneal environment early after endometriotic lesion establishment and remain present in murine lesions long term. In vivo neutrophil depletion altered the systemic and peritoneal immune microenvironment of mice with endometriosis as demonstrated by changes in pro-inflammatory and angiogenic mediators. Taken together, these findings highlight a novel role for neutrophils in early events such as angiogenesis and modulation of the local inflammatory environment associated with endometriosis pathogenesis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Neutrophils Animals Animals Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Inflammation Inflammation Inflammation Mice Mice

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (72)

Cited by (47)

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