Measurement of hs-CRP is irrelevant to diagnose and stage endometriosis: prospective study of 834 patients

Thubert T, Thibault Thubert, Pietro Santulli, Santulli P, Piétro Santulli, Marcellin L, Louis Marcellin, Sophie Menard, Sophie Ménard, Menard S, M'Baye M, Magatte Mbaye, Magatte M'Baye, Isabelle Streuli, Bruno Borghese, Dominique de Ziegler, de Ziegler D, Charles Chapron, Chapron C
American journal of obstetrics and gynecology · 2014 · vol. 210(6) , pp. 533.e1–533.e10 · doi:10.1016/j.ajog.2014.01.022 · PMID:24440563 · W2067070956
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High-sensitivity C-reactive protein (hs-CRP) measurement is not relevant for diagnosing or staging endometriosis, as demonstrated in a prospective study of 834 patients.

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Abstract

OBJECTIVE: The pathogenesis of endometriosis is associated with an inflammatory process. Here, we assessed if the levels of high-sensitivity C-reactive protein (hs-CRP) in serum could constitute an effective method for detecting systemic inflammation during endometriosis. STUDY DESIGN: This was a prospective, laboratory-based study, which was carried out in a tertiary care university hospital. Patients with histologically proven endometriosis (n = 370) and unaffected women (n = 464) were enrolled from January 2005 through December 2009. We performed complete surgical excision of endometriotic lesions with pathological analysis. In addition, hs-CRP levels were determined through a particle-enhanced immunoturbidimetric method. The hs-CRP levels were measured in both controls and women with endometriosis according to the established surgical classifications of endometriosis: superficial peritoneal endometriosis, endometrioma, and deep infiltration endometriosis. Also, hs-CRP levels were evaluated according to hormonal treatment and menstrual cycle. RESULTS: The hs-CRP serum levels did not statistically differ between women with endometriosis and controls (median in ng/mL [range]: 0.82 [0.04-42.89] vs 0.9 [0.03-43.73], respectively; P = .599). Moreover, subgroup analysis revealed no difference among superficial peritoneal endometriosis, endometrioma, deep infiltration endometriosis, and controls: 0.8 (0.15-13.35), 0.81 (0.04-38.82), 0.83 (0.09-42.89), and 0.9 (0.03-43.73), respectively; P = .872. Furthermore, no effect was observed regarding hormonal treatment or menstrual cycle. CONCLUSION: Although endometriosis is an inflammatory disease, we failed to identify any systemic changes in hs-CRP serum levels. Therefore, hs-CRP analysis appears to be irrelevant to the diagnosis and staging of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

C-Reactive Protein Endometriosis Inflammation Adult Adult Case-Control Studies Case-Control Studies C-Reactive Protein C-Reactive Protein Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans Inflammation Inflammation Inflammation

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