Identification of endometriosis molecular regulatory axes through bioinformatics analysis: insights into lncRNAs, miRNAs, and mRNAs

Shahrzad Zhaeentan, Fardin Amidi, Ashraf Moini, Seyed Danial Mohammadi, Aligholi Sobhani, Masoomeh Nataj Majd, Mahshad Khodarahmian
2025 · doi:10.61882/phypha.29.2.155 · W7081953262
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This bioinformatics study identified dysregulated lncRNAs, miRNAs (including miR-6500-3p), and hub genes (like CDH1, ESR1) in endometriosis, revealing implications for embryonic organ morphogenesis and immune response.

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Abstract

Introduction: Endometriosis (EMS) is a highly prevalent gynecological disorder with substantial health consequences, affecting as many as 10% of women in their reproductive years.Although EMS is widespread, its intricate origin and pathophysiology are not well understood.This study investigated the molecular characteristics of EMS by examining the expression patterns of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and genes linked to the condition.Methods: The study used publicly accessible datasets, namely RNA-seq data for long non-coding RNAs (GSE105764), miRNA expression data (GSE105765), and gene expression data (GSE12768), to compare samples of ectopic and eutopic endometrial samples.The study conducted differential expression analysis, pathway enrichment analyses, protein-protein interaction network creation, and hub gene identification to uncover the molecular markers linked to EMS.Results: The investigation identified substantial dysregulation of lncRNAs, miRNAs, and genes in endometriotic tissues compared with the control eutopic endometrium.Hub genes, including CDH1, ESR1, GATA4, PGR, FOXA2, EPCAM, APOA1, BDNF, FGFR2, and PAX2, dominate the molecular landscape.miR-6500-3p has been identified as a pivotal regulator that influences the expression of seven essential genes.Pathway enrichment analysis identified biological processes, including embryonic organ morphogenesis, immunological response, and medication metabolism.Exploring lncRNA-mediated regulatory axes, particularly H19 and MIR600HG, suggests complex networks that may clarify the molecular underpinnings of EMS.Conclusion: This thorough investigation offers significant insight into the molecular pathways underlying EMS.Hub genes and regulatory miRNAs, including miR-6500-3p, have been identified as prospective targets for therapeutic interventions.Pathway enrichment studies provide a more comprehensive understanding of the biological processes implicated in EMS, indicating new possibilities for therapeutic interventions.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (57)

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