Endometrioma size is a relevant factor in selection of the most appropriate surgical technique: a prospective randomized preliminary study

Giampaolino P, P. Giampaolino, Pierluigi Giampaolino, G Bifulco, Giuseppe Bifulco, A Di Spiezio Sardo, Attilio Di Spiezio Sardo, Di Spiezio Sardo A, A. Mercorio, Antonio Mercorio, Dario Bruzzese, D Bruzzese, Costantino Di Carlo, C Di Carlo
European journal of obstetrics, gynecology, and reproductive biology · 2015 · vol. 195 , pp. 88–93 · doi:10.1016/j.ejogrb.2015.09.046 · PMID:26492167 · W2142100085
RCT OA: closed CC0 ⤵ 30 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study prospectively randomized patients to compare surgical techniques for endometriomas, finding endometrioma size is a relevant factor in selecting the most appropriate method.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVES: To assess and compare the ovarian reserve in patients with different-sized endometriomas undergoing cystectomy or ablative surgery in order to determine the best surgical approach to safeguard healthy ovarian tissue. STUDY DESIGN: Prospective randomized study on 48 patients with unilateral single ovarian endometriomas. Patients were allocated into two groups based on endometrioma size: <5cm (n=26, Group A, small endometriomas) and ≥5cm (n=22, Group B, large endometriomas). Each group was randomized to coagulation or excision treatment (1:1 ratio) before the procedure. Anti-Müllerian hormone (AMH) levels were evaluated before surgery and 3 months after surgery. RESULTS: Both ablation and excision resulted in a significant reduction in AMH level regardless of endometrioma size. A significant interaction effect was observed between endometrioma size and type of surgical technique (analysis of covariance p for interaction=0.039): in Group A, no significant difference was found between the two surgical techniques (-17.6±4.7% vs -18.2±10.6%), whereas in Group B, the excision group showed a significantly greater percentage decrease in AMH level compared with the ablation group (-24.1±9.3% vs -14.8±6.7%, p=0.011). CONCLUSIONS: Both ablative and excision treatment of endometriomas have a negative effect on ovarian function. Endometrioma size is associated with the magnitude of ovarian reserve damage following excision treatment, but in the case of ablative treatment, the decrease in AMH serum level is independent of the size of the cyst. In surgical treatment of large endometriomas, the decrease in AMH level is more consistent and much more severe following cystectomy than ablation.

My notes (saved in your browser only)

Condition tags

endometriosisendometrioma

MeSH descriptors

Electrocoagulation Electrocoagulation Endometriosis Ovarian Cysts Ovarian Diseases Ovarian Reserve Ovarian Reserve Ovary Adult Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Anti-Mullerian Hormone Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (35)

Cited by (31)

Source provenance

europepmc
last seen: 2026-10-25T09:32:14.900964+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:16:42.682428+00:00
License: CC0 · commercial use OK