An unusual clinical presentation and histological findings provide insight into the pathogenesis of endometriosis

PD Simpson, Xenia Tyler, X Tyler, EP Morris
Gynecological Surgery · 2016 · vol. 13(4) , pp. 479–484 · doi:10.1007/s10397-016-0984-y · W2530985655
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

A patient with endometriosis presented with a rapidly growing cyst containing an endometriotic implant within an excised pelvic lymph node, highlighting the potential role of the lymphatic system in the disease's pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper reports an unusual endometriosis case in a 37-year-old woman with known disease who developed a rapidly enlarging endometrioma after prior surgical drainage, ultimately requiring laparotomy and right salpingo-oophorectomy for severe pain. Surgery revealed marked retroperitoneal inflammation and fibrosis, and a 2.5 cm pelvic lymph node was excised; histology identified a cystic structure interpreted as an endometriotic cyst within the lymph node. The authors note that the clinical significance is unknown, but the findings highlight a possible role for the lymphatic system in endometriosis pathogenesis, while acknowledging uncertainty. This paper is centrally about endometriosis — it uses a lymph node–involving clinical and histological case to discuss possible lymphatic involvement in disease pathogenesis.

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endometriosis

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