Letrozole and norethisterone acetate in colorectal endometriosis

Simone Ferrero, Camerini G, Giovanni Camerini, Ragni N, Nicola Ragni, Venturini PL, Pier Luigi Venturini, Pier L Venturini, Ennio Biscaldi, Biscaldi E, Renato Seracchioli, Valentino Remorgida
European journal of obstetrics, gynecology, and reproductive biology · 2010 · vol. 150(2) , pp. 199–202 · doi:10.1016/j.ejogrb.2010.02.023 · PMID:20227163 · W2112000579
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated the efficacy of letrozole and norethisterone acetate in treating colorectal endometriosis.

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Abstract

ObjectiveUp to now limited attention has been given to the medical treatment of bowel endometriosis. This study evaluates the efficacy of aromatase inhibitors and norethisterone acetate in treating pain and gastrointestinal symptoms caused by bowel endometriosis.Study designThis prospective pilot study included six women with colorectal endometriosis; all women had intestinal nodules infiltrating at least the muscularis propria of the bowel and did not have a stenosis of the bowel lumen >60%; the patients suffered from pain and intestinal symptoms. The study subjects received letrozole (2.5 mg/day) and norethisterone acetate (2.5 mg/day) continuously for 6 months. The presence and intensity of symptoms were evaluated before starting the treatment, and after 3 and 6 months of treatment.ResultsThe double-drug regimen improved pain, non-menstrual pelvic pain, deep dyspareunia, dyschezia, symptoms mimicking diarrhoea-predominant irritable bowel syndrome, intestinal cramping, abdominal bloating and passage of mucus in the stools, and 67% of the patients declared that the treatment improved their gastrointestinal symptoms.ConclusionsThe administration of letrozole and norethisterone acetate reduces pain and gastrointestinal symptoms of women with colorectal endometriosis, particularly when patients suffer from symptoms mimicking diarrhoea-predominant irritable bowel syndrome.

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Condition tags

dyspareuniaendometriosischronic_pelvic_pain

MeSH descriptors

Colonic Diseases Endometriosis Nitriles Norethindrone Rectal Diseases Triazoles Abdominal Pain Abdominal Pain Aromatase Inhibitors Aromatase Inhibitors Colonic Diseases Diarrhea Diarrhea Drug Therapy, Combination Dyspareunia Dyspareunia Endometriosis Female Humans Letrozole

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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