Use of aromatase inhibitors in menopausal deep endometriosis: a case report and literature review

O. Rotenberg, D Y S Kuo, Kuo DYS, Gary L. Goldberg, G L Goldberg, Goldberg GL
Climacteric : the journal of the International Menopause Society · 2021 · vol. 25(3) , pp. 235–239 · doi:10.1080/13697137.2021.1990259 · PMID:34694933 · W3208344897
review OA: bronze CC0
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Aromatase inhibitors, like letrozole, demonstrate clinical, radiological, and endoscopic effectiveness in treating refractory deep infiltrating endometriosis, especially in postmenopausal women, and should be considered in the management of difficult cases.

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Abstract

We report and review the clinical effectiveness of aromatase inhibitors in a patient with refractory, recurrent and infiltrating endometriosis. We demonstrate excellent clinical, radiological and endoscopic responses after failure of multiple other modalities. Our case and the literature show that single-agent letrozole is capable to treat deep infiltrative endometriosis involving the rectum and the urinary tract. The use of aromatase inhibitor treatment of endometriosis in postmenopausal women makes sense, is safe and is well tolerated. Difficult cases of deep infiltrative endometriosis might require use of combined surgical and medical treatment modalities. Multidisciplinary involvement of the gynecologist, bowel surgeon, urologist and invasive radiologist might be needed. Aromatase inhibitors should be considered to be an integral part of the armamentarium in the management of women with endometriosis, especially in refractory cases that have failed conventional therapeutic modalities.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Inhibitors Aromatase Inhibitors Endometriosis Endometriosis Endometriosis Aromatase Aromatase Female Humans Letrozole Letrozole Menopause Rectum

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (1)

SciLite annotations

chemicals 1
letrozole

Source provenance

europepmc
last seen: 2026-09-21T06:08:07.822426+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
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License: CC0 · commercial use OK