Insertion of mirena after endometrial resection in patients with adenomyosis
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Mirena insertion immediately after endometrial resection increased amenorrhea rates and eliminated the need for repeat procedures in women with adenomyosis-related menorrhagia.
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Abstract
STUDY OBJECTIVE: To evaluate the efficacy of Mirena, a levonorgestrel-releasing intrauterine device, after endometrial resection for treatment of menorrhagia caused by adenomyosis.
DESIGN: Open, randomized, observational study (Canadian Task Force classification II-2).
SETTING: Private hospital.
PATIENTS: Ninety-five women.
INTERVENTION: Endometrial resection, after which control patients received no further treatment and study patients had Mirena inserted immediately after the procedure.
MEASUREMENTS AND MAIN RESULTS: The rate of amenorrhea after 1 year was significantly higher in the Mirena group. Nineteen percent of women in the control group had a second procedure to control bleeding compared with none in the Mirena group.
CONCLUSION: Insertion of Mirena after endometrial resection is effective treatment for menorrhagia caused by adenomyosis and has very few adverse effects.
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- Levonorgestrel Intrauterine Device versus Combined Transcervical Resection of the Endometrium in the Management of Adenomyosis: A Randomized Clinical Trial 2026
- Long-term efficacy and safety of levonorgestrel releasing intrauterine system in the treatment of adenomyosis: evidence mapping 2024
- The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis 2023
- Long-term Efficacy and Safety of Levonorgestrel - releasing Intrauterine System in the Treatment of Adenomyosis: Evidence Mapping and Meta-analysis 2022
- Medical Treatment of Adenomyosis 2022
- A systematic review of outcome reporting and outcome measures in studies investigating uterine-sparing treatment for adenomyosis 2021
- A controlled clinical trial comparing potent progestins, LNG-IUS and dienogest, for the treatment of women with adenomyosis 2021
- Current and Prospective Treatment of Adenomyosis 2021
- Adenomyotic Cyst at Menopause Transition: A Combined Treatment 2020
- Conservative Surgery in the Management of Adenomyosis 2019
- Faculty Opinions recommendation of The impact of adenomyosis on women's fertility. 2019
- The effect of transcervical endometrial resection on clinical symptoms related to intrinsic adenomyosis and junctional zone changes 2019
- Minimally invasive treatment of adenomyosis 2018
- Operation, hormone therapy and recovery of the patients with severe forms of adenomyosis 2018
- Combination of microwave endometrial ablation and postoperative dienogest administration is effective for treating symptomatic adenomyosis 2018
- Adenomyosis and Hysteroscopy: An Up-to-Date Review 2017
- Adenomyosis and Hysteroscopy: An Up-to-Date Review 2017
- The Role of the Myometrium in Adenomyosis 2015
- Levonorgestrel-releasing intrauterine system versus a low-dose combined oral contraceptive for treatment of adenomyotic uteri: a randomized clinical trial 2015
- Adenomiosis: tratamiento 2015
- Levonorgestrel-releasing intrauterine system versus low-dose combined oral contraceptive for treatment of adenomyosis uteri: a randomized clinical trial 2015
- Current Treatment for Adenomyosis 2015
- The effect of oral contraceptives on aromatase and Cox-2 expression in the endometrium of patients with idiopathic menorrhagia or adenomyosis 2013
- Effect of a hormone-releasing intrauterine system (Mirena(®)) on aromatase and Cox-2 expression in patients with adenomyosis submitted or not, to endometrial resection 2012
- Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis 2011
- Activation of NF-κB and COX-2 expression is associated with breakthrough bleeding in patients using oral contraceptives in extended regimens 2010
- The effect of hysterectomy or levonorgestrel-releasing intrauterine system on lower abdominal pain and back pain among women treated for menorrhagia: a five-year randomized controlled trial 2009
- Safety, efficacy and patient acceptability of the contraceptive and non-contraceptive uses of the LNG-IUS 2009
- Levonorgestrelį išskiriančios gimdos spiralės vartojimas ginekologijoje 2009
- Adenomyosis uteri: an update 2009
- [Management of menometrorrhagia in women with and without pregnancy intention: hierarchy of therapies] 2008
- Clinical effects of the levonorgestrel-releasing intrauterine device in patients with adenomyosis 2008
- Non-contraceptive health benefits of oral contraceptives 2008
- Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies 2008
- Traitement de l'adénomyose 2007
- Tratamiento de la adenomiosis 2007
- The levonorgestrel-releasing intrauterine system: an updated review of the contraceptive and noncontraceptive uses 2007
- Hormonal treatments for adenomyosis 2007
- Re-audit: transcervical resection of the endometrium for heavy menstrual bleeding and the treatment of post-resection uterine stenosis and haematometra by cervical dilatation and the insertion of a levonorgestrel-releasing intra-uterine system 2006
- New interventional techniques for adenomyosis 2006
- Medicated intrauterine systems for treatment of endometriosis-associated pain 2006
- The role of magnetic resonance imaging in minimal access surgery 2006
- Effect of the menstrual cycle and oral contraceptives on aromatase and cyclooxygenase-2 expression in adenomyosis 2006
- Non-contraceptive uses of levonorgestrel-releasing hormone system (LNG-IUS)--a systematic enquiry and overview 2005
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- europepmc
- last seen: 2026-10-11T09:27:45.537177+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:02:19.201584+00:00
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