Combination of microwave endometrial ablation and postoperative dienogest administration is effective for treating symptomatic adenomyosis

Kuniaki Ota, Takahashi T, Toshifumi Takahashi, Satoru Shiraishi, Shiraishi S, Hideki Mizunuma, Mizunuma H
Journal of Obstetrics and Gynaecology Research · 2018 · vol. 44(9) , pp. 1787–1792 · doi:10.1111/jog.13720 · PMID:29998482 · W2848923292
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This study evaluated the combination of microwave endometrial ablation and postoperative dienogest, finding it effectively reduced pain and anemia in women with symptomatic adenomyosis.

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Abstract

AIM: Menorrhagia and dysmenorrhea are common symptoms. Uterine adenomyosis is one of the causes of menorrhagia and dysmenorrhea. These symptoms often decrease the quality of life in women. Microwave endometrial ablation (MEA) is a recently developed procedure that enables endometrial ablation. Dienogest has long been used to suppress endometrium development and reduce adenomyosis-related dysmenorrhea. However, some cases could be resistant to dienogest. In this study, we evaluated the efficacy of a combination of MEA and postoperative dienogest in reducing adenomyosis-related dysmenorrhea and menorrhagia. METHODS: Ten patients with hormone treatment-resistant symptomatic adenomyosis underwent MEA and were administered oral dienogest after the procedure. The primary endpoints were reduction in pain recurrence and anemia. The secondary endpoint was a change in the adenomyosis lesion and its symptomatic recurrence. RESULTS: Statistically significant improvements were seen in the visual analog scale score and hemoglobin levels in women post-treatment. The difference in myometrial thickness pre- and post-MEA was statistically significant. There were no cases of symptomatic recurrence. CONCLUSION: The combination of MEA and postoperative dienogest is useful for treating uterine adenomyosis with menorrhagia and dysmenorrhea.

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Condition tags

dysmenorrheaadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometrial Ablation Techniques Hormone Antagonists Menorrhagia Menorrhagia Menorrhagia Menorrhagia Microwaves Nandrolone Outcome Assessment, Health Care Adult Combined Modality Therapy Endometrial Ablation Techniques

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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