Case of adenomyosis causing the activation of the coagulation system after a complete loss of endometrium following microwave endometrial ablation

Fuminori Kimura, Tetsuro Hanada, Akiko Nakamura, Tsukuru Amano, Shunichiro Tsuji, Nobuyuki Kita, Takashi Murakami
Journal of Obstetrics and Gynaecology Research · 2021 · vol. 47(9) , pp. 3385–3391 · doi:10.1111/jog.14898 · PMID:34137116 · W3166998588
article OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This case report describes a patient with adenomyosis who exhibited marked activation of the coagulation system, evidenced by elevated thrombin-antithrombin and soluble fibrin levels, despite the absence of uterine bleeding following microwave endometrial ablation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The formation of microbleed and minute tissue necrosis inside adenomyosis after the shedding of endometrial or endometrial-like tissue within the myometrium during menstruation is receiving attention as a new pathological condition of uterine adenomyosis. These formations might greatly affect coagulation and fibrinolysis function. However, these modulations might occur due to indirect effects of massive hemorrhage from the uterus with adenomyosis. We present a case of adenomyosis in which the patient's coagulation system was markedly activated despite the absence of menstruation due to previous microwave endometrial ablation to prevent massive uterine hemorrhage. Although no uterine bleeding was observed at all, the patient's serum levels of thrombin-antithrombin complex and soluble fibrin were abnormally elevated at the time when she complained of lower abdominal pain. As the first such case in the world, the present case is valuable for showing that the coagulation function can be modified by uterine adenomyosis.

My notes (saved in your browser only)

Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Endometrial Ablation Techniques Endometrium Endometrium Female Humans Microwaves

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (4)

Source provenance

europepmc
last seen: 2026-06-13T17:20:28.795615+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:31.988741+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: CC0 · commercial use OK