Successful long-term management of adenomyosis associated with deep thrombosis by low-dose gonadotropin-releasing hormone agonist therapy.
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Low-dose gonadotropin-releasing hormone agonist therapy successfully managed a patient's adenomyosis and deep vein thrombosis while preserving her uterus and resolving symptoms.
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Abstract
We report the case of a patient with adenomyosis complicated by deep vein thrombosis in whom low-dose gonadotropin-releasing hormone agonist (GnRHa) therapy was useful as a uterus-conserving therapeutic option. The patient was a 34-year-old nulliparous woman who presented with edema and pain in the left lower leg. The patient had been treated with four cycles of GnRHa therapy for adenomyosis and repeatedly experienced chronic pelvic pain, dysmenorrhea and anemia due to hypermenorrhea. Leg venography confirmed deep vein thrombosis, and thrombolytic therapy was performed to eliminate symptoms. Because the patient strongly wanted to conserve the uterus, low-dose GnRHa therapy was initiated. The patient is currently taking 450 microg/day buserelin acetate nasally (regular dose: 900 microg/day), and estradiol levels have been maintained at 24-50 pg/ml. Anemia, leg numbness and chronic pelvic pain have dissipated, and the patient has not experienced estrogen deficiency symptoms for more than two years.
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Cited by (10)
- Recurrent Cerebral Infarction Associated with Uterine Adenomyosis 2022
- Case of adenomyosis causing the activation of the coagulation system after a complete loss of endometrium following microwave endometrial ablation 2021
- Acute right lower limb deep venous thrombosis due to pressure from large adenomyotic uterus-laparoscopic management 2020
- Recurrence of uterine adenomyosis after administration of gonadotropin-releasing hormone agonist and the efficacy of dienogest 2019
- Efficacy of hormonal therapies for decreasing uterine volume in patients with adenomyosis 2018
- Drug therapy for adenomyosis: a prospective, nonrandomized, parallel-controlled study 2018
- Low-dose gonadotropin-releasing hormone agonist therapy (draw-back therapy) for successful long-term management of adenomyosis associated with cerebral venous and sinus thrombosis from low-dose oral contraceptive use 2017
- Dysfunctional coagulation and fibrinolysis systems due to adenomyosis is a possible cause of thrombosis and menorrhagia 2016
- Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition 2015
- Norethindrone Acetate in the Medical Management of Adenomyosis 2012
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- europepmc
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- openalex
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- pubmed
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