Recurrent Cerebral Infarction Associated with Uterine Adenomyosis
This paper reports a woman with uterine adenomyosis who experienced recurrent cerebral infarctions, highlighting adenomyosis as an under-recognized cause of stroke due to a hypercoagulable state.
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This paper reports a 49-year-old woman with uterine adenomyosis who experienced four episodes of recurrent cerebral infarction over about 7 years, investigated with serial neuroimaging, cardiac/vascular embolic workups (including transesophageal/transthoracic echocardiography and 24-hour Holter monitoring), and repeated coagulation and tumor-marker testing. The key finding is that, during acute infarction periods, she had markedly elevated D-dimer and mucinous tumor markers CA125 and CA19-9 alongside a substantially enlarged adenomyotic uterus, while embolic sources were not identified; major caveats include that the report is based on a single case and does not establish causality or pinpoint the exact mechanism beyond the suggested hypercoagulable link. Treatment included antiplatelet and later anticoagulation (eventually warfarin), with hormonal therapy (leuprolide) and gynecologic management decisions affecting recurrence. This paper is centrally about endometriosis—specifically uterine adenomyosis—because it describes recurrent cerebral infarction episodes attributed to adenomyosis-associated hypercoagulability and related elevations in CA125/CA19-9 and D-dimer.
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References (10)
- Acute cerebral infarction with adenomyosis in a patient with fever: a case report via openalex
- Acute disseminated intravascular coagulation developed during menstruation in an adenomyosis patient via openalex
- Cerebral infarction associated with benign mucin-producing adenomyosis: report of two cases via openalex
- Cerebral Infarction Developing in A Patient Without Cancer With A Markedly Elevated Level of Mucinous Tumor Marker via openalex
- Cerebral Infarcts Associated with Adenomyosis Among Middle-aged Women via openalex
- Cerebral infarcts associated with adenomyosis: a rare risk factor for stroke in middle-aged women: a case series via openalex
- “Recurrent multiple cerebral infarctions related to the progression of adenomyosis: a case report” via openalex
- Successful long-term management of adenomyosis associated with deep thrombosis by low-dose gonadotropin-releasing hormone agonist therapy. via openalex
- W2412367714 via openalex
- W2033970555 via openalex
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- last seen: 2026-06-10T17:14:06.276822+00:00