Cerebral Infarction Developing in A Patient Without Cancer With A Markedly Elevated Level of Mucinous Tumor Marker

Yamashiro K, Kazuo Yamashiro, Furuya T, Tsuyoshi Furuya, Noda K, Kazuyuki Noda, Takao Urabe, Urabe T, Nobutaka Hattori, Yasuyuki Okuma, Okuma Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2011 · vol. 21(7) , pp. 619.e1–619.e2 · doi:10.1016/j.jstrokecerebrovasdis.2010.12.007 · PMID:21277226 · W1982280034
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This case report details a patient who developed a cerebral infarction with a markedly elevated mucinous tumor marker, despite no evidence of cancer.

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Abstract

Previous studies have shown the possible role of mucin in cerebral infarction associated with coagulation abnormalities in patients with cancer, particularly adenocarcinoma. We report a 42-year-old woman who developed motor aphasia and cerebral infarction in the left frontal lobe and right parietal lobe. A mucinous tumor marker, CA125 level, was markedly elevated at 1750 U/mL (normal, <36 U/mL), and the D-dimer level was 6.0 μg/mL (normal, <1 μg/mL). She had adenomyosis and no malignancy was revealed. The CA125 and the D-dimer levels became normal after treatment of adenomyosis. Our findings suggest for the first time that marked elevation of mucinous tumor marker level may cause cerebral infarction even in benign conditions.

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MeSH descriptors

Adenomyosis CA-125 Antigen Cerebral Infarction Frontal Lobe Parietal Lobe Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adult Aphasia, Broca Aphasia, Broca CA-125 Antigen Cerebral Infarction Cerebral Infarction Cerebral Infarction Female Fibrin Fibrinogen Degradation Products Fibrin Fibrinogen Degradation Products Frontal Lobe

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