Factors Associated with Changes in Coagulation Function in Patients with Adenomyopathy

伊 法拉·地里木拉提
In: Advances in Clinical Medicine · 2024 · vol. 14(04) , pp. 514–518 · doi:10.12677/acm.2024.1441053 · W4394697861
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Factors influencing coagulation function changes in adenomyopathy patients include estrogen levels, uterine size, anemia, neovascularization, and inflammatory factors, which interact to drive these alterations.

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This review examines the factors associated with coagulation function changes in patients diagnosed with adenomyopathy, a condition characterized by the growth of endometrial glands and stroma within the uterine myometrium. The authors identify that elevated estrogen levels, increased uterine size, anemia, neovascularization, and inflammatory factors interact to promote a hypercoagulable state, thereby increasing the risk of thrombotic diseases such as stroke or venous thromboembolism. The paper synthesizes existing literature to highlight how these physiological alterations contribute to clinical symptoms like menorrhagia and severe dysmenorrhea while underscoring the systemic impact of the disease on hemostasis. This paper is centrally about adenomyosis — specifically focusing on the pathophysiological mechanisms linking the disease to altered coagulation profiles and thrombotic risk.

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引起子宫腺肌病患者凝血功能变化的相关因素 Factors Associated with Changes in Coagulation Function in Patients with Adenomyopathy Factors Associated with Changes in Coagulation Function in Patients with Adenomyopathy DOI: 10.12677/acm.2024.1441053, PDF, 被引量 作者: 伊法拉·地里木拉提, 阿比达·阿不都卡德尔*：新疆医科大学第一附属医院妇科，新疆 乌鲁木齐 关键词: 子宫腺肌病；凝血功能；综述；Adenomyopathy； Coagulation Function； Review 作者: 伊法拉·地里木拉提, 阿比达·阿不都卡德尔*：新疆医科大学第一附属医院妇科，新疆 乌鲁木齐 关键词: 子宫腺肌病；凝血功能；综述；Adenomyopathy； Coagulation Function； Review 摘要: 子宫腺肌病是一种常见的妇科疾病，主要由子宫内膜腺体及间质在子宫肌层生长引起。临床症状主要表现为月经过多(甚至致严重贫血)、严重痛经、不孕、子宫增大等。近些年来有国内外报道指出，子宫腺肌病患者并发血栓性疾病的风险较高，由此可推测子宫腺肌病患者的凝血功能可能存在异常。目前涉及引起子宫腺肌病患者凝血功能发生改变的因素较为广泛，其可包括雌激素水平、子宫体积大小、贫血、新生血管形成、炎症因子等，各因素间相互作用，共同促进子宫腺肌病患者凝血功能变化的发生与进展。 Abstract: Adenomyopathy is a common gynecological disease, mainly caused by the growth of endometrial glands and stroma in the myometrium. The main clinical symptoms are menorrhagia (even severe anemia), severe dysmenorrhea, infertility, uterine enlargement and so on. In recent years, it has been reported at home and abroad that patients with adenomyopathy have a higher risk of thrombotic diseases, so it can be inferred that there may be abnormal coagulation function in patients with adenomyopathy. At present, there are a wide range of factors involved in the change of coagulation function in patients with adenomyopathy, including estrogen level, uterine size, anemia, neovascularization, inflammatory factors, etc. All factors interact with each other to jointly promote the occurrence and progress of coagulation function changes in patients with adenomyopathy. 文章引用：伊法拉·地里木拉提, 阿比达·阿不都卡德尔. 引起子宫腺肌病患者凝血功能变化的相关因素[J]. 临床医学进展, 2024, 14(4): 514-518. https://doi.org/10.12677/acm.2024.1441053 | [1] | 丁萍萍, 王长林. 青春期子宫腺肌病中西医病因病机研究进展[J]. 中国中医药现代远程教育, 2022, 20(24): 200-202. | | [2] | 赵丽, 李玉英, 袁芳. Ninj1, IL-1β在子宫腺肌病和子宫内膜异位症中的表达及意义[J]. 临床医学进展, 2021, 11(7): 3277-3282. [Google Scholar] [CrossRef] | | [3] | 吴晚英. 子宫腺肌病的临床诊疗研究进展[J]. 实用妇科内分泌电子杂志, 2023, 10(6): 36-39. | | [4] | Zhai, J.Y., et al. (2020) Adenomyosis: Mechanisms and Pathogenesis. Seminars in Reproductive Medicine, 38, 129-143. [Google Scholar] [CrossRef] [PubMed] | | [5] | 潘兆兰, 罗茜茜. 子宫腺肌病保守治疗研究进展[J]. 河北中医, 2023, 45(9): 1580-1584. | | [6] | 丁梦凯, 顾振鹏, 刘志慧, 等. 子宫腺肌症药物治疗的研究进展[J]. 实用妇科内分泌电子杂志, 2022, 9(2): 47-50. | | [7] | 谭爱丽, 洛若愚, 龚梦. 子宫腺肌病病灶切除术前使用GnRH-a预处理的价值[J]. 中华妇产科杂志, 2016, 51(12): 909-913. | | [8] | 沈晓宇, 刘明越. 子宫腺肌病血栓前状态和凝血因子变化的效果[J]. 中国医药指南, 2022, 20(2): 86-89. | | [9] | 覃克敏, 隆海银, 陈基云, 等. 子宫腺肌病相关脑梗死的临床特点分析[J]. 现代妇产科进展, 2019, 28(2): 133-135. | | [10] | 张会媛, 王安琪, 王霞, 等. 子宫腺肌病发生血栓性病变的风险及临床特点[J]. 国际妇产科学杂志, 2022, 49(3): 250-255. | | [11] | Hong, E.Y., Lin, H.Z. and Fong, Y.F. (2020) Venous Thromboembolism and Adenomyosis: A Retrospective Review. Gynecology and Minimally Invasive Therapy, 9, 64-68. [Google Scholar] [CrossRef] | | [12] | Cernogoraz, A., Schiraldi, L., Bonazza, D., et al. (2019) Menstruation-Related Disseminated Intravascular Coagulation in an Adenomyosis Patient: Case Report and Review of the Literature. Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology, 35, 32-35. [Google Scholar] [CrossRef] [PubMed] | | [13] | 孙媛媛. TGF-β1和CTGF与子宫腺肌病纤维化的相关性研究[D]: [硕士学位论文]. 石家庄: 河北医科大学, 2021. | | [14] | 成萍, 纪燕琴, 周明辉, 等. 子宫腺肌病患者芳香化酶P450、环氧合酶2及雌、孕激素受体表达的研究[J]. 中国基层医药, 2015, 22(3): 326-329. | | [15] | 陆黎娟, 方晓慧, 孙园园, 等. 滋肾清心法对子宫腺肌病患者GnRH-a治疗后低雌激素症状和性激素水平的影响[J]. 广西医学, 2022, 44(13): 1545-1548. | | [16] | 杜清. 性激素水平变化与肺动脉血栓栓塞症(PTE)发病的相关性研究[J]. 健康女性, 2021(39): 95. | | [17] | Bazot, M. and Dara, E. (2018) Role of Transvaginal Sonography and Magnetic Resonance Imaging in the Diagnosis of Uterine Adenomyosis. Fertility & Sterility, 109, 389-397. [Google Scholar] [CrossRef] [PubMed] | | [18] | 卢佳, 胡兵, 李欢. MRI及超声评估子宫腺肌病患者子宫内膜-肌层交界区研究进展[J]. 中国医学影像技术, 2022, 38(8): 1262-1265. | | [19] | 李金皎, 段华, 汪沙, 等. 子宫腺肌病患者子宫肌层平滑肌细胞生长状态与增殖特点的研究[J]. 中国计划生育和妇产科, 2016, 8(5): 29-34. | | [20] | 子宫腺肌病伴不孕症诊疗中国专家共识编写组. 子宫腺肌病伴不孕症诊疗中国专家共识[J]. 中华生殖与避孕杂志, 2021, 41(4): 287-295. [Google Scholar] [CrossRef] | | [21] | 王俊文, 张凤花, 付强, 等. 重度痛经的弥漫性子宫腺肌病子宫内膜-肌层交界区神经病理改变初步探讨[J]. 实用妇科内分泌电子杂志, 2017, 4(2): 126-128. | | [22] | 王丽平, 汪沙, 张颖, 等. 雌二醇对子宫腺肌病患者子宫内膜-肌层交界区平滑肌细胞游离Ca2 调节模式的初步研究[J]. 中华妇产科杂志, 2012, 47(5): 351-354. | | [23] | 潘臧钰. 不同月经周期子宫腺肌病患者与健康人群阴道微生物组的差异[D]: [硕士学位论文]. 济南: 山东大学, 2023. | | [24] | 张德玉, 彭超, 周应芳, 等. 子宫腺肌病患者凝血功能的改变及其临床意义[J]. 中华妇产科杂志, 2020, 55(11): 749‑753. | | [25] | 王慧莹, 刘木彪. 子宫内膜异位症抗血管生成治疗的研究进展[J]. 妇产与遗传(电子版), 2012, 2(4): 36-40. | | [26] | 陈慧, 郎茂竹, 王婧, 等. 下调环状RNA Hsa-circ-PVT1对子宫腺肌病异位子宫内膜间质细胞增殖、侵袭及血管生成作用机制的影响[J]. 现代妇产科进展, 2023, 32(3): 182-187. | | [27] | 孙瑶琦, 蒋惠慈, 刘洁. 炎症因子与子宫腺肌病发病机制研究进展[J]. 国际妇产科学杂志, 2020, 47(1): 96-100. | | [28] | Kimura, F., Hanada, T., et al. (2021) Case of Adenomyosis Causing the Activation of the Coagulation System after a Complete Loss of Endometrium Following Microwave Endometrial Ablation. The Journal of Obstetrics and Gynaecology Research, 47, 3385-3391. [Google Scholar] [CrossRef] [PubMed] |

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