The impact of endometriosis on early embryo morphokinetics: a case-control study

Fazilet Kübra Boynukalın, Boynukalin FK, Fazilet Kubra Boynukalin, Serdarogullari M, Munevver Serdarogullari, Münevver Serdarogullari, Meral Gültomruk, Gultomruk M, Meral Gultomruk, Önder Coban, Necati Findikli, Necati Fındıklı, Mustafa Bahceci, Mustafa Bahçeci, Bahceci M
Systems biology in reproductive medicine · 2019 · vol. 65(3) , pp. 250–257 · doi:10.1080/19396368.2019.1573275 · PMID:30741013 · W2914331392
Observational OA: bronze CC0 ⤵ 11 in-corpus citations
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Endometriosis significantly distorts the first cell cycle duration and the time between t3 and t4 in early embryo development compared to controls.

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Abstract

The aim of this study was to evaluate the possible effects of endometriosis on early embryo development, by comparing the morphokinetic development of embryos obtained from women with clinically confirmed endometriosis with the ones obtained from tubal factor infertility cases. A total of 82 cycles/patients including 53 cycles with endometriosis and 29 cycles with tubal factor infertility were evaluated. A total of 439 embryos were scored for embryo morphokinetics. Age, body mass index, fertilization rates were similar within the groups. However, the number of previous ART trials was found to be higher (p < 0.05) in the study group. Also, the number of retrieved oocytes and M2 oocytes were found to be significantly lower in patients with endometriosis (p < 0.01). The duration of the first cell cycle (ECC1) and S2 (the time between t3 and t4) displayed significant distortions compared with embryos in the control group. All other analyzed early morphokinetic parameters (t2, t3, t4, t5, t6, t7, t8) and duration of events (VP, cc2a, ECC2, ECC3, S3) showed similar values between study and control groups, respectively. In the light of these findings, it is apparent that endometriosis predominantly affects the duration of the early morphokinetic events and cell cycles.

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Condition tags

endometriosis

MeSH descriptors

Embryonic Development Embryonic Development Endometriosis Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (2-hop)

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