A randomized, double-blind, placebo-controlled pilot study of the comparative effects of dienogest and the combined oral contraceptive pill in women with endometriosis

Mehdizadeh Kashi A, Abolfazl Mehdizadeh Kashi, Niakan G, Gelareh Niakan, Ebrahimpour M, Majid Ebrahimpour, Leila Allahqoli, Hassanlouei B, Babak Hassanlouei, Georgios Gitas, Gitas G, İbrahim Alkatout, Alkatout I
International Journal of Gynecology & Obstetrics · 2021 · vol. 156(1) , pp. 124–132 · doi:10.1002/ijgo.13677 · PMID:33728657 · W3136748212
RCT OA: bronze CC0 ⤵ 28 in-corpus citations
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This pilot study found that postoperative dienogest or a combined oral contraceptive pill reduced endometriosis pain and improved quality of life compared to placebo in women with severe endometriosis.

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Abstract

OBJECTIVE: To compare the effects of dienogest and a combined oral contraceptive pill (COCP) after laparoscopic surgery on pain and quality of life in women with severe endometriosis. METHODS: A randomized double-blind pilot study was conducted from March 2018 to March 2020 in women with severe endometriosis confirmed by laparoscopic surgery. A total of 108 patients who had undergone laparoscopic surgery received dienogest, COCP, or placebo daily for 6 months. Primary and secondary outcomes were compared between the three groups. RESULTS: Treatment with dienogest or COCP was associated with improved self-reported pain after 6 months of treatment, as evidenced by significantly lower scores for pelvic pain and dyspareunia compared with placebo (P < 0.05). Significant differences in overall quality of life score were observed over 6 months in the dienogest, COCP, and placebo groups (mean difference 22.00, 23.45, and 6.45 points, respectively; P < 0.001). Post-hoc analysis revealed a significant difference in overall quality of life score between the placebo group and the dienogest (P < 0.001) and COCP groups (P = 0.004). CONCLUSION: Postoperative administration of dienogest or COCP reduced endometriosis-associated pain and improved quality of life in women with severe endometriosis. CLINICAL TRIALS REGISTRATION: https://en.irct.ir/trial/43070.

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Condition tags

endometriosisdyspareunia

MeSH descriptors

Endometriosis Endometriosis Endometriosis Nandrolone Nandrolone Nandrolone Contraceptives, Oral, Combined Contraceptives, Oral, Combined Female Female Humans Humans Pilot Projects Pilot Projects Quality of Life Quality of Life

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (32)

Cited by (31)

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