Effects of anti-TNF-mAb treatment on pregnancy in baboons with induced endometriosis

Henrik Falconer, Jason M. Mwenda, Mwenda JM, Daniel Chai, Daniel C Chai, Song XY, Xioa-yu R. Song, Freddy Cornillie, Freddy J Cornillie, Cornillie FJ, Agneta Bergqvist, Bergqvist A, Gabriel Fried, Fried G, Thomas D’Hooghe, Thomas M D'Hooghe, D'Hooghe TM
Fertility and sterility · 2007 · vol. 89(5) , pp. 1537–1545 · doi:10.1016/j.fertnstert.2007.05.062 · PMID:17765236 · W2129506277
Lab / animal OA: closed CC0 ⤵ 22 in-corpus citations
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This study investigated the effects of anti-TNF-mAb treatment on induced endometriosis in pregnant baboons, assessing outcomes related to the condition and pregnancy.

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Abstract

OBJECTIVE: Hormonal suppressive therapy is not effective for endometriosis-associated subfertility and can even prevent conception. Medical inhibition of TNFalpha, which has been shown to improve conception, is effective in the prevention and treatment of endometriosis in baboons. DESIGN: Prospective, placebo-controlled fertility trial. SETTING: Animal research and laboratory facility. ANIMAL(S): Sixteen adult female baboons with induced endometriosis. INTERVENTION(S): All animals received a single IV dose of the anti-TNFalpha monoclonal antibody c5N (n = 9) or placebo (n = 7) at four different time points. The animals were then exposed to timed mating up to nine completed cycles or until pregnancy was achieved. MAIN OUTCOME MEASURE(S): Pregnancy rate (PR), cycle fecundity rate (CFR), time to pregnancy (TTP), and cumulative pregnancy rate (CPR). RESULT(S): Inhibition of TNFalpha did not result in a significant improvement in PR (100% c5N vs. 86% placebo), CFR (18% c5N vs. 30% placebo), median TTP (5 cycles c5N vs. 2 cycles placebo), or CPR (100% c5N vs. 80% placebo). The duration of the menstrual cycle was unchanged in both groups before and after the study. Two nonpregnant baboons in the c5N-group died during the study. CONCLUSION(S): Medical inhibition of TNFalpha allowed for normal conception but did not improve fecundity in baboons with induced endometriosis when compared with placebo. Larger studies with clinically available TNFalpha blockers in baboons with moderate to severe endometriosis are needed to further test the potential of these agents in the prevention or treatment of endometriosis-associated subfertility.

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Condition tags

endometriosis

MeSH descriptors

Antibodies, Monoclonal Endometriosis Infertility, Female Papio Papio Pregnancy, Animal Pregnancy, Animal Tumor Necrosis Factor-alpha Algorithms Algorithms Animals Animals Antibodies, Monoclonal Antibodies, Monoclonal Antibodies, Monoclonal Drug Evaluation, Preclinical Drug Evaluation, Preclinical Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (22)

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