[TNF-alpha secretion by peritoneal macrophages in endometriosis]
Observational
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CC0
⤵ 20 in-corpus citations
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This study found significantly higher TNF-alpha concentrations in peritoneal fluid of endometriosis patients, correlating with disease severity.
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Abstract
Beside of other cytokines and growth-factors Tumor Necrosis Factor Alpha (TNF-alpha) exerts as a macrophage-derived cytotoxic product a variety of immunologic effects in the human organism. It is also an important angiogenetic factor and regarding its cytotoxicity toward gametes TNF-alpha plays an essential role as pelvine mediator of sterility. The purpose of our study was to evaluate the TNF-alpha-synthesis of Peritoneal-Macrophages (PM) in patients with and without endometriosis and to determine if a correlation exists between TNF-alpha-synthesis and various degrees of the activity of endometriosis. For reasons of sterility 40 women underwent diagnostic laparoscopy and were staged according to the rAFS-classification as well as the macroscopic aspect of activity into a control group with endometriosis-free pelvic situs (n = 14) and three subgroups characterized by the increasing stage of the disease (n = 26). The TNF-alpha-concentrations (median) in the control group were 3.3 pg/ml, in group 2 with stage I/II rAFS and only low active endometriosis 60.2 pg/ml, in group 3 with stage I/II rAFS but high active endometriosis 83.2 pg/ml and in group 3 with stage III/IV rAFS 168 pg/ml. These data were statistically high significant and showed good conformity with the histological findings. We found significant higher TNF-alpha-concentrations in the peritoneal fluid of patients with endometriosis than in the peritoneal fluid of healthy women. There is a correlation between TNF-alpha-concentrations and the degree of disease.
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Cited by (20)
- Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P 2022
- Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators 2022
- O inibidor Btk Ibrutinib limita o desenvolvimento da endometriose em camundongos 2021
- Effects of Gallic Acid and Its Derivates on Inflammatory Regulation of Endometriotic Primary Cultures: Study on NF-kB mRNA Expression and IL-6 Secretion 2018
- Immunology of endometriosis 2018
- Fas-Related Apoptosis of Peritoneal Fluid Macrophages in Endometriosis Patients: Understanding the Disease 2017
- C-reactive protein of serum and peritoneal fluid in endometriosis 2012
- Efeitos do sistema intra-uterino de Levonorgestrel sobre marcadores de risco cardiovascular de pacientes com endometriose: estudo comparativo com o análogo do GnRH 2009
- Evaluation of the effect of pentoxifylline on white blood cell count in serum and peritoneal fluid in female rats with endometriosis 2008
- Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample 2007
- Endometriose und Inflammation 2007
- Is endometriosis associated with systemic subclinical inflammation? 2006
- Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large? 2006
- Endometriosis: epidemiology and aetiological factors 2004
- Deficient expression of tumor necrosis factor receptor type 2 in the endometrium of women with endometriosis 2003
- Differentialdiagnose und Behandlungsstrategien bei Endometriose: Was tun - wann? 2003
- Endometriosis is sustained by tumour necrosis factor-alpha 2002
- Therapie der Endometriose unter Berücksichtigung der Aktivitätsgrade 2002
- Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis 2002
- Increased insulin-like growth factor 1 activity can rescue KLE endometrial-like cells from apoptosis 2001
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- europepmc
- last seen: 2026-10-17T06:09:56.316927+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T22:00:41.816812+00:00
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