Pharmacology of danazol

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Danazol was found to be an orally active pituitary gonadotrophin inhibitor with weak androgenic activity, lacking oestrogenic and progestational effects, and demonstrated safety in toxicological studies.

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Abstract

We have established that danazol is an orally active pituitary gonadotrophin inhibitory agent devoid of oestrogenic and progestational activity. This steroid has weak, impeded androgenic activity. Danazol is unique in possessing such a profound separation of pituitary gonadotrophin inhibitory activity from overt sex hormone activity. Separate studies have shown that danazol is antiandrogenic, anti-progestational and antioestrogenic. Extensive toxicological studies have established the safety of this steroid. Lastly, the metabolic studies provide convincing evidence that danazol is the active steroid.

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MeSH descriptors

Danazol Pregnadienes Animals Castration Chemical Phenomena Chemistry Danazol Dogs Female Genitalia, Male Genitalia, Male Haplorhini Macaca mulatta Male Mice Ovary Ovary Pregnadienes Rabbits Rats

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openalex
last seen: 2026-05-10T10:49:45.548917+00:00
pubmed
last seen: 2026-10-08T21:51:55.209427+00:00
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